{"title":"Polyhydroxyalkanes from <i>Pachysandra terminalis</i> Sieb. et Zucc.","authors":"Yuying Zhang, Chenwang Liu, Chuanming Gong, Yao Wu, Yu Sun, Yuze Li, Wei Wang, Xiaomei Song, Dongdong Zhang","doi":"10.1080/14786419.2024.2441497","DOIUrl":null,"url":null,"abstract":"<p><p>Four polyhydroxyalkanes were isolated from the CH<sub>2</sub>Cl<sub>2</sub> part of <i>Pachysandra terminalis</i>, including two new ones, (2<i>S</i>,3<i>E</i>)-3-isopropylpent-3-ene-1,2,5-triol (<b>1</b>) and (4<i>R</i>,2<i>E</i>)-4,5-dihydroxy-2,3-dimethylpent-2-enoic acid (<b>2</b>); as well as one new natural product, 3-methylbut-3-ene-1,2-diol (<b>3</b>) and one known compound, 4-methyl-3-methylenepentane-1,2-diol (<b>4</b>). The structures were determined by physicochemical properties and spectroscopic methods including 1D, 2D NMR, IR, HR-ESI-MS, and ECD data. The cytotoxic activity of compounds against the human cancer lines A549, H460, and HepG2 cell lines of the isolated compounds was evaluated by the CCK8 method. However, compounds did not show significant activity.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.6000,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2024.2441497","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Four polyhydroxyalkanes were isolated from the CH2Cl2 part of Pachysandra terminalis, including two new ones, (2S,3E)-3-isopropylpent-3-ene-1,2,5-triol (1) and (4R,2E)-4,5-dihydroxy-2,3-dimethylpent-2-enoic acid (2); as well as one new natural product, 3-methylbut-3-ene-1,2-diol (3) and one known compound, 4-methyl-3-methylenepentane-1,2-diol (4). The structures were determined by physicochemical properties and spectroscopic methods including 1D, 2D NMR, IR, HR-ESI-MS, and ECD data. The cytotoxic activity of compounds against the human cancer lines A549, H460, and HepG2 cell lines of the isolated compounds was evaluated by the CCK8 method. However, compounds did not show significant activity.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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