Risk Factors for Extrapulmonary Tuberculosis Among US Veterans, 1990-2022.

IF 3.8 4区医学 Q2 IMMUNOLOGY Open Forum Infectious Diseases Pub Date : 2024-11-27 eCollection Date: 2024-12-01 DOI:10.1093/ofid/ofae698

Gina Oda, Cynthia Lucero-Obusan, Patricia Schirmer, Joyce Chung, Mark Holodniy

{"title":"Risk Factors for Extrapulmonary Tuberculosis Among US Veterans, 1990-2022.","authors":"Gina Oda, Cynthia Lucero-Obusan, Patricia Schirmer, Joyce Chung, Mark Holodniy","doi":"10.1093/ofid/ofae698","DOIUrl":null,"url":null,"abstract":"Purpose: To determine factors that put US veterans with active tuberculosis at risk for extrapulmonary tuberculosis (EPTB) compared with pulmonary tuberculosis.Methods: We included veterans with laboratory-confirmed tuberculosis from 1990-2022 in our retrospective cohort study. Multivariable logistic regression was used to estimate the association of demographic and clinical risk factors with EPTB.Results: Of 7493 veterans aged 20-100 years (median, 58 years) with laboratory-confirmed tuberculosis, 1397 (19%) had EPTB. The most common EPTB infection among veterans was pleural (31.4%), while meningitis carried the highest mortality risk at 90 days. Factors independently associated with EPTB among veterans were non-Hispanic black race/ethnicity, diabetes mellitus, human immunodeficiency virus infection, severe kidney disease, and all-cause mortality within 90 days after tuberculosis diagnosis.Conclusions: Our study demonstrated several risk factors for EPTB among US veterans. Healthcare providers should be educated regarding patient populations at risk for EPTB, especially given the challenges in diagnosing this disease and the importance of instituting early treatment to prevent severe illness and death.","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"11 12","pages":"ofae698"},"PeriodicalIF":3.8000,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639626/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open Forum Infectious Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/ofid/ofae698","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: To determine factors that put US veterans with active tuberculosis at risk for extrapulmonary tuberculosis (EPTB) compared with pulmonary tuberculosis.

Methods: We included veterans with laboratory-confirmed tuberculosis from 1990-2022 in our retrospective cohort study. Multivariable logistic regression was used to estimate the association of demographic and clinical risk factors with EPTB.

Results: Of 7493 veterans aged 20-100 years (median, 58 years) with laboratory-confirmed tuberculosis, 1397 (19%) had EPTB. The most common EPTB infection among veterans was pleural (31.4%), while meningitis carried the highest mortality risk at 90 days. Factors independently associated with EPTB among veterans were non-Hispanic black race/ethnicity, diabetes mellitus, human immunodeficiency virus infection, severe kidney disease, and all-cause mortality within 90 days after tuberculosis diagnosis.

Conclusions: Our study demonstrated several risk factors for EPTB among US veterans. Healthcare providers should be educated regarding patient populations at risk for EPTB, especially given the challenges in diagnosing this disease and the importance of instituting early treatment to prevent severe illness and death.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

1990-2022 年美国退伍军人肺外结核病的风险因素。

目的：确定与肺结核相比，活动性肺结核的美国退伍军人发生肺外结核（EPTB）风险的因素。方法：我们在回顾性队列研究中纳入了1990-2022年实验室确诊结核病的退伍军人。采用多变量logistic回归估计人口统计学和临床危险因素与EPTB的关系。结果：7493例20 ~ 100岁退伍军人（中位年龄58岁）实验室确诊结核，其中1397例（19%）为EPTB。退伍军人中最常见的EPTB感染是胸膜（31.4%），而脑膜炎在90天内的死亡率最高。与退伍军人EPTB独立相关的因素包括非西班牙裔黑人种族/民族、糖尿病、人类免疫缺陷病毒感染、严重肾脏疾病和结核病诊断后90天内的全因死亡率。结论：我们的研究显示了美国退伍军人中EPTB的几个危险因素。应教育卫生保健提供者了解EPTB的高危患者人群，特别是考虑到诊断这种疾病的挑战以及制定早期治疗以预防严重疾病和死亡的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Open Forum Infectious Diseases Medicine-Neurology (clinical)

CiteScore

6.70

自引率

4.80%

发文量

630

审稿时长

9 weeks

期刊介绍： Open Forum Infectious Diseases provides a global forum for the publication of clinical, translational, and basic research findings in a fully open access, online journal environment. The journal reflects the broad diversity of the field of infectious diseases, and focuses on the intersection of biomedical science and clinical practice, with a particular emphasis on knowledge that holds the potential to improve patient care in populations around the world. Fully peer-reviewed, OFID supports the international community of infectious diseases experts by providing a venue for articles that further the understanding of all aspects of infectious diseases.