Systemic Antibiotic Prophylaxis Adjunctive to Surgical Reconstructive Peri-Implantitis Treatment: A Retrospective Study

IF 3.7 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Clinical Implant Dentistry and Related Research Pub Date : 2024-12-15 DOI:10.1111/cid.13429

Ausra Ramanauskaite, Ioanna Saltzer, Ninad Padhye, Amira Begic, Karina Obreja, Iulia Dahmer, Frank Schwarz

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Abstract

Aims

To evaluate the clinical efficacy of oral systemic antibiotic prophylaxis administered along with the surgical reconstructive peri-implantitis treatment.

Methods

A total of 49 patients exhibiting 70 implants diagnosed with peri-implantitis underwent a surgical reconstructive peri-implantitis treatment. Of them, 27 patients (38 implants) received a single preoperative shot of antibiotics (2 g amoxicillin; Pre-op), 12 patients (19 implants) were prescribed with postoperative antibiotics for 3 days (500 mg amoxicillin, 3 x day, Post-op), and the remaining 10 patients (13 implants) did not receive any systemic antibiotics (No-Ab). Mean probing depth values (mean PDs; primary outcome), bleeding on probing (BOP), plaque (PI), suppuration (Sup), and deepest PDs values (max PD) were assessed prior to surgery (baseline), after 6 and 12 months. To assess the differences in changes in the clinical parameters, and disease resolution (PD ≤ 5 mm, ≤ 1 BOP site and no Sup) among the groups, logistic regression analyses were performed.

Results

After 12 months, the mean PD reduction amounted to −1.74 ± 1.56 mm, −1.91 ± 1.88 mm, and −1.13 ± 1.05 mm in the No-Ab, Pre-op, and Post-op groups, respectively, with no significant difference detected among the groups. The BOP was reduced in 60%, 59.3%, and 83.3% of the patients after 12 months in the No-Ab, Pre-op, and Post-op groups, respectively, with no significant differences among them. The PI, Sup and max PD reductions were comparable among the groups. Disease resolution after 12 months was established in 61.5%, 73.7%, and 89.5% of patients in the No-Ab, Pre-op, and Post-op groups (No-Ab vs. Pre-op: p = 0.10, No-Ab vs. Post-op: p = 0.40, Pre-op vs. Post-op: p = 0.84).

Conclusion

Systemic antibiotic prophylaxis did not improve the clinical outcomes of surgical reconstructive peri-implantitis treatment.

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系统性抗生素预防辅助外科整形种植体周围炎治疗：一项回顾性研究。

目的：评估口服全身抗生素预防性治疗与外科重建性种植体周围炎治疗的临床疗效：共有 49 名患者的 70 个种植体被诊断为种植体周围炎，并接受了种植体周围炎外科整形治疗。其中，27 例患者（38 个种植体）术前使用了一次抗生素（2 克阿莫西林；术前），12 例患者（19 个种植体）术后使用了 3 天抗生素（500 毫克阿莫西林，3 x 天，术后），其余 10 例患者（13 个种植体）未使用任何系统抗生素（无抗生素）。对术前（基线）、术后 6 个月和 12 个月的平均探诊深度值（平均探诊深度；主要结果）、探诊出血量（BOP）、牙菌斑（PI）、化脓（Sup）和最深探诊深度值（最大探诊深度）进行了评估。为了评估各组间临床参数变化和疾病缓解（PD ≤ 5 mm、BOP ≤ 1 个部位和无 Sup）的差异，进行了逻辑回归分析：12个月后，无抗体组、术前组和术后组的平均PD分别为-1.74±1.56 mm、-1.91±1.88 mm和-1.13±1.05 mm，组间无显著差异。12 个月后，无抗体组、术前组和术后组分别有 60%、59.3% 和 83.3% 的患者 BOP 下降，组间无明显差异。各组的 PI、Sup 和最大 PD 下降幅度相当。12个月后，无抗生素组、术前组和术后组分别有61.5%、73.7%和89.5%的患者病情得到缓解（无抗生素组与术前组对比：P = 0.10；无抗生素组与术后组对比：P = 0.40；术前组与术后组对比：P = 0.84）：结论：全身性抗生素预防并不能改善外科整形种植体周围炎治疗的临床效果。

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来源期刊

Clinical Implant Dentistry and Related Research 医学-牙科与口腔外科

CiteScore

6.00

自引率

13.90%

发文量

103

审稿时长

4-8 weeks

期刊介绍： The goal of Clinical Implant Dentistry and Related Research is to advance the scientific and technical aspects relating to dental implants and related scientific subjects. Dissemination of new and evolving information related to dental implants and the related science is the primary goal of our journal. The range of topics covered by the journals will include but be not limited to: New scientific developments relating to bone Implant surfaces and their relationship to the surrounding tissues Computer aided implant designs Computer aided prosthetic designs Immediate implant loading Immediate implant placement Materials relating to bone induction and conduction New surgical methods relating to implant placement New materials and methods relating to implant restorations Methods for determining implant stability A primary focus of the journal is publication of evidenced based articles evaluating to new dental implants, techniques and multicenter studies evaluating these treatments. In addition basic science research relating to wound healing and osseointegration will be an important focus for the journal.