Investigating the shared genetic architecture between anxiety and stroke.

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES Behavioural Brain Research Pub Date : 2025-03-05 Epub Date: 2024-12-15 DOI:10.1016/j.bbr.2024.115400

Yichen Zhang, Yong'An Jiang, Hengyi Fan, Raorao Yuan, Jianhui Cai, Bo Zhong, Qian Qin, Zile Zhang, Yan Zhang, Shiqi Cheng

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引用次数: 0

Abstract

Background: An epidemiological association between anxiety and stroke is well-established; however, the role of shared genetic factors remain unclear. This study aimed to investigate the shared genetic architecture between anxiety and stroke.

Methods: Using public genome-wide association study (GWAS) summary statistics of anxiety and stroke, we performed linkage disequilibrium score regression and super genetic covariance analyzer for global and local genetic correlation studies. Risk single nucleotide polymorphisms (SNPs) were identified through genome-wide association meta-analysis, multi-trait analysis of GWAS and PLINK, followed by functional mapping and annotation. Additionally, we conducted transcriptome-wide association studies to explore the relationship between genes and associated disease risk.

Results: Our analysis revealed a significant genome-wide genetic correlation between anxiety and stroke. We also identified one previously unreported significant SNP (rs62099231), one risk loci, as well as identified three shared risk genes for anxiety and stroke (WDR6, CCDC71, NCKIPSD).

Conclusion: Our study demonstrated a shared genetic structure between anxiety and stroke, enhancing our understanding of their pathogenesis and highlighting potential therapeutic targets.

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研究焦虑和中风之间的共同遗传结构。

背景：焦虑和中风之间的流行病学关联已经确立；然而，共同遗传因素的作用仍不清楚。本研究旨在探讨焦虑和中风之间的共同遗传结构。方法：利用公开的全基因组关联研究（GWAS）汇总统计数据，对焦虑与脑卒中进行连锁不平衡评分回归和超遗传协方差分析，对全球和局部遗传相关性进行研究。通过全基因组关联荟萃分析、GWAS和PLINK多性状分析，确定风险单核苷酸多态性（snp），并进行功能作图和注释。此外，我们进行了全转录组关联研究，以探索基因与相关疾病风险之间的关系。结果：我们的分析揭示了焦虑和中风之间显著的全基因组遗传相关性。我们还发现了一个以前未报道的显著SNP (rs62099231)，一个风险位点，以及三个焦虑和中风的共同风险基因（WDR6, CCDC71， NCKIPSD）。结论：我们的研究表明焦虑和中风之间存在共同的遗传结构，增强了我们对其发病机制的理解，并突出了潜在的治疗靶点。

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来源期刊

Behavioural Brain Research 医学-行为科学

CiteScore

5.60

自引率

0.00%

发文量

383

审稿时长

61 days

期刊介绍： Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.