The effects of costly telomere maintenance on lifespan - reproductive tradeoffs in sand lizards.

IF 3.1 2区 环境科学与生态学 Q2 ECOLOGY Evolution Pub Date : 2024-12-17 DOI:10.1093/evolut/qpae181
Mats Olsson, Emily Miller, Nicky Rollings, Mette Lillie, Joshua Hufton, Alexander Hansson, Erik Wapstra
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Abstract

Telomeres are DNA-protein structures that primarily protect chromosomes and serve multiple functions of gene regulation. When cells divide, telomeres shorten and their main repair system in ectotherms - telomerase - replaces lost nucleotide complexes ((T2AG3)n in vertebrates). It remains a challenge to experimentally investigate resource requirements for telomere maintenance and its effects on lifespan-reproductive tradeoffs in the wild. In sand lizards (Lacerta agilis), we show that higher female investments into reproduction results in corresponding shortening of telomeres and that males have less frequent and less profound telomere shortening than females; a contributing factor to this may be males' higher telomerase levels. To manipulate resource access for telomere maintenance, we exploit a pseudo-experimental opportunity to analyze 'onboard' resources long-term using lizards that drop their tails with fat and nutrient deposits when attacked by predators. Females with less resources due to regrown tails less often and less profoundly elongate telomeres. Adult lizards with the most TL elongation live the longest, females with the highest lifetime reproductive success shorten telomeres the most, whereas males with the most telomere elongation have the highest lifetime reproductive success. This suggests ongoing evolution of resource-constrained telomere maintenance.

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代价高昂的端粒维护对沙蜥寿命的影响--生殖权衡。
端粒是一种 DNA 蛋白结构,主要保护染色体,并具有多种基因调控功能。当细胞分裂时,端粒会缩短,外温动物的主要修复系统--端粒酶--会取代丢失的核苷酸复合物(脊椎动物为(T2AG3)n)。在野外通过实验研究端粒维持的资源需求及其对寿命-生殖权衡的影响仍然是一个挑战。在沙蜥(Lacerta agilis)中,我们发现雌性对繁殖的较高投入会导致端粒的相应缩短,而雄性端粒缩短的频率和程度都低于雌性;其中一个原因可能是雄性端粒酶水平较高。为了操纵端粒维持的资源获取,我们利用了一个伪实验机会,利用蜥蜴在受到捕食者攻击时尾部的脂肪和营养沉积物掉落来分析 "机载 "资源的长期性。由于尾巴重新生长,资源较少的雌性端粒拉长的频率和深度都较低。端粒伸长最多的成年蜥蜴寿命最长,终生繁殖成功率最高的雌性蜥蜴端粒缩短最多,而端粒伸长最多的雄性蜥蜴终生繁殖成功率最高。这表明资源受限的端粒维护正在不断进化。
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来源期刊
Evolution
Evolution 环境科学-进化生物学
CiteScore
5.00
自引率
9.10%
发文量
0
审稿时长
3-6 weeks
期刊介绍: Evolution, published for the Society for the Study of Evolution, is the premier publication devoted to the study of organic evolution and the integration of the various fields of science concerned with evolution. The journal presents significant and original results that extend our understanding of evolutionary phenomena and processes.
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The effects of costly telomere maintenance on lifespan - reproductive tradeoffs in sand lizards. Digest: Habitat associations shape a hybrid zone in killifish. The evolution of a placenta accelerates the evolution of post-copulatory reproductive isolation. Correction to: Allometric scaling of somatic mutation and epimutation rates in trees. An empirical test of Baker's law: Dispersal favors increased rates of self-fertilization.
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