Xin Li, Wen Zheng, Long Han, Zhang-Jiang He, Ji-Chuan Kang
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引用次数: 0
Abstract
A new aglycone derivative (1) and five known compounds (2-6) have been isolated from a saprophytic fungus Tubeufia rubra for the first time. Their structures and absolute configurations were determined by nuclear magnetic resonance, high resolution mass spectrometry data and electronic circular dichroism. The bioactivities of all compounds were evaluated by cell analysis. Compound 5 showed significant toxicity to human cancer A549 cells, and the IC50 value was 32. 89 μg/mL. Compound 6 could reverse the multidrug resistance of A549/DDP cells, and the reversal value was 2.92. With the extension of the action time, the IC50 value of compound 6 decreased from 424.72 μg/mL at 24 h to 9.45 μg/mL at 72 h.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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