Prognosis for patients with metastatic conjunctival melanoma

IF 3.7 2区 医学 Q1 OPHTHALMOLOGY British Journal of Ophthalmology Pub Date : 2024-12-18 DOI:10.1136/bjo-2024-326271
Bita Esmaeli
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Abstract

Conjunctival melanoma is a rare ocular cancer, and despite recent advances in the early detection of metastasis and the availability of new drugs such as immune checkpoint inhibitors and Braf-directed targeted therapy that have demonstrated efficacy for the treatment of metastatic conjunctival melanoma,1 it remains a significant cause of morbidity and mortality worldwide. Jain et al report on 29 patients with metastatic conjunctival melanoma.2 These 29 patients represent about 10% of the 288 patients with conjunctival melanoma included in this retrospective review based on data pooled from 10 international centres from a wide geographic area of the world. ‘Metastasis’ is defined as ‘M1’ per the American Joint Commission on Cancer (AJCC) definition and as such only addresses distant (hematogenous) metastasis. In other words, the stated primary objective of the report is to focus on patients who developed hematogenous distant metastasis although the authors provide some information regarding nodal metastasis in the same group of patients. Among the 29 patients with systemic metastasis, five (17%) were found at the time of the initial presentation, while 24 (83%) were …
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转移性结膜黑色素瘤患者的预后
结膜黑色素瘤是一种罕见的眼部癌症,尽管近来在早期发现转移方面取得了进展,免疫检查点抑制剂和布拉夫定向靶向疗法等新药也已证明对治疗转移性结膜黑色素瘤具有疗效,1 但它仍然是全球发病率和死亡率的一个重要原因。Jain 等人报告了 29 例转移性结膜黑色素瘤患者的情况。2 这 29 例患者约占这项回顾性研究中 288 例结膜黑色素瘤患者的 10%,而这项研究是根据来自全球广泛地区的 10 个国际中心的数据汇集而成的。根据美国癌症联合委员会(AJCC)的定义,"转移 "被定义为 "M1",因此只涉及远处(血源性)转移。换句话说,虽然作者提供了同组患者结节转移的一些信息,但报告的主要目标是关注发生血源性远处转移的患者。在 29 例全身转移的患者中,有 5 例(17%)是在初次发病时发现的,而 24 例(83%)是在...
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来源期刊
CiteScore
10.30
自引率
2.40%
发文量
213
审稿时长
3-6 weeks
期刊介绍: The British Journal of Ophthalmology (BJO) is an international peer-reviewed journal for ophthalmologists and visual science specialists. BJO publishes clinical investigations, clinical observations, and clinically relevant laboratory investigations related to ophthalmology. It also provides major reviews and also publishes manuscripts covering regional issues in a global context.
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