Synthesis and Biological Properties of Hybrid Compounds Based on Nitrogen-Containing Heterocycles and 1,5-Disubstituted 3,7-Diazabicyclo[3.3.1]nonan-9-ones
A. A. Harutyunyan, S. G. Israelyan, M. R. Hakobyan, M. S. Safaryan, R. A. Madoyan, A. G. Sukiasyan, K. A. Gevorkyan, A. D. Harutyunyan, A. S. Sargsyan, A. A. Hambardzumyan, H. A. Karapetyan, A. A. Mnatsakanyan, H. A. Panosyan, M. Yu. Danghyan, S. P. Gasparyan
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引用次数: 0
Abstract
The reaction of aromatic aldehydes and 3-(heteryl)methyl-4-methoxybenzaldehydes with 1,5-disubstituted 3,7-diazabicyclo[3.3.1]nonan-9-ones afforded 2-aryl(hetaryl)-5,7-dimethyl-1,3-diazaadamantane-6-ones. 3-(Heteryl)methyl-4-methoxybenzaldehydes were obtained by alkylation of nitrogen-containing heterocycles (N1-functionalized uracil and 5-halouracils, N3-functionalized 6-methylpyrimidin- and quinazolin-4(3H)-ones, benzotriazole, quinoline, benzoxazole) with 3-chloromethyl-4-methoxylbenzaldehyde. Antibacterial and fungicidal properties of the synthesized compounds were studied.
期刊介绍：
Russian Journal of General Chemistry is a journal that covers many problems that are of general interest to the whole community of chemists. The journal is the successor to Russia’s first chemical journal, Zhurnal Russkogo Khimicheskogo Obshchestva (Journal of the Russian Chemical Society ) founded in 1869 to cover all aspects of chemistry. Now the journal is focused on the interdisciplinary areas of chemistry (organometallics, organometalloids, organoinorganic complexes, mechanochemistry, nanochemistry, etc.), new achievements and long-term results in the field. The journal publishes reviews, current scientific papers, letters to the editor, and discussion papers.
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