Stem Cell Therapies and Ageing: Unlocking the Potential of Regenerative Medicine.

Q1 Biochemistry, Genetics and Molecular Biology Sub-cellular biochemistry Pub Date : 2024-01-01 DOI:10.1007/978-3-031-66768-8_6

Chen Rui, Mike K S Chan, Thomas Skutella

{"title":"Stem Cell Therapies and Ageing: Unlocking the Potential of Regenerative Medicine.","authors":"Chen Rui, Mike K S Chan, Thomas Skutella","doi":"10.1007/978-3-031-66768-8_6","DOIUrl":null,"url":null,"abstract":"<p><p>A multifaceted biological process of ageing culminates in the gradual decline of tissue and organ functions, escalating vulnerability to age-related diseases. Stem cell therapies, standing at the frontier of regenerative medicine, hold the potential to mitigate the challenges induced by ageing. By harnessing the unique regenerative capabilities of stem cells, these therapies aim to renew and heal ageing or damaged cells and tissues, thereby bolstering their function. In this chapter, we explore the potential of stem cell-based interventions against age-related degeneration, emphasising their underlying mechanisms, challenges, and future possibilities. As elucidated by the Buck Institute for Research on Aging, ageing is characterised by an accrual of macromolecular damage, genomic instability, and loss of heterochromatin (Campisi et al. Nature 571:183-192, 2019). These aspects culminate in stem cell fatigue and a dwindling tissue regenerative capacity. However, with the advent of stem cell therapy and regenerative medicine, we now hold the tools to reverse these age-induced changes by rejuvenating stem cells, the keystones of tissue regeneration, and fostering their proliferation and differentiation.</p>","PeriodicalId":21991,"journal":{"name":"Sub-cellular biochemistry","volume":"107 ","pages":"117-128"},"PeriodicalIF":0.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sub-cellular biochemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/978-3-031-66768-8_6","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}

引用次数: 0

Abstract

A multifaceted biological process of ageing culminates in the gradual decline of tissue and organ functions, escalating vulnerability to age-related diseases. Stem cell therapies, standing at the frontier of regenerative medicine, hold the potential to mitigate the challenges induced by ageing. By harnessing the unique regenerative capabilities of stem cells, these therapies aim to renew and heal ageing or damaged cells and tissues, thereby bolstering their function. In this chapter, we explore the potential of stem cell-based interventions against age-related degeneration, emphasising their underlying mechanisms, challenges, and future possibilities. As elucidated by the Buck Institute for Research on Aging, ageing is characterised by an accrual of macromolecular damage, genomic instability, and loss of heterochromatin (Campisi et al. Nature 571:183-192, 2019). These aspects culminate in stem cell fatigue and a dwindling tissue regenerative capacity. However, with the advent of stem cell therapy and regenerative medicine, we now hold the tools to reverse these age-induced changes by rejuvenating stem cells, the keystones of tissue regeneration, and fostering their proliferation and differentiation.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

干细胞疗法与衰老：释放再生医学的潜力。

衰老是一个多方面的生物过程，最终导致组织和器官功能逐渐下降，对年龄相关疾病的脆弱性不断上升。干细胞疗法，站在再生医学的前沿，有可能减轻由衰老引起的挑战。通过利用干细胞独特的再生能力，这些疗法旨在更新和治愈老化或受损的细胞和组织，从而增强其功能。在本章中，我们探讨了干细胞干预对抗年龄相关变性的潜力，强调了它们的潜在机制、挑战和未来的可能性。巴克衰老研究所（Buck Institute for Research on Aging）指出，衰老的特征是大分子损伤的累积、基因组的不稳定性和异染色质的丧失（Campisi等）。Nature 571:183-192, 2019)。这些方面最终导致干细胞疲劳和组织再生能力下降。然而，随着干细胞疗法和再生医学的出现，我们现在掌握了通过使干细胞（组织再生的关键）恢复活力并促进其增殖和分化来逆转这些年龄引起的变化的工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Sub-cellular biochemistry Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

5.90

自引率

0.00%

发文量

期刊介绍： The book series SUBCELLULAR BIOCHEMISTRY is a renowned and well recognized forum for disseminating advances of emerging topics in Cell Biology and related subjects. All volumes are edited by established scientists and the individual chapters are written by experts on the relevant topic. The individual chapters of each volume are fully citable and indexed in Medline/Pubmed to ensure maximum visibility of the work.

期刊最新文献

Basic Epigenetic Mechanisms. Environmental Enrichment and Epigenetic Changes in the Brain: From the Outside to the Deep Inside. Epigenetic Control in Schizophrenia. Epigenetics in Learning and Memory. Epigenetics in Neurodegenerative Diseases.