Do tissue-dwelling trypanosomes sustain transmission populations?

IF 6.6 1区 医学 Q1 PARASITOLOGY Trends in parasitology Pub Date : 2025-01-01 Epub Date: 2024-12-16 DOI:10.1016/j.pt.2024.12.001
Stephen D Larcombe, Jane C Munday, Richard McCulloch
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引用次数: 0

Abstract

Trypanosoma brucei infectious populations are marked by considerable diversity in the parasite's major antigen, the variant surface glycoprotein (VSG). However, most parasites in the bloodstream are non-replicating, questioning how VSG diversity arises. Beaver et al. show that extravascular parasites in host tissues many explain this paradox and provide insight into trypanosome transmission.

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生活在组织中的锥虫能维持传播种群吗?
布鲁氏锥虫感染人群的特点是其主要抗原变异表面糖蛋白(VSG)具有相当大的多样性。然而,血液中的大多数寄生虫都是不复制的,这就质疑了VSG多样性是如何产生的。Beaver等人的研究表明,宿主组织中的血管外寄生虫可以解释这一悖论,并为锥虫的传播提供了见解。
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来源期刊
Trends in parasitology
Trends in parasitology 医学-寄生虫学
CiteScore
14.00
自引率
3.10%
发文量
148
审稿时长
6-12 weeks
期刊介绍: Since its inception as Parasitology Today in 1985, Trends in Parasitology has evolved into a highly esteemed review journal of global significance, reflecting the importance of medical and veterinary parasites worldwide. The journal serves as a hub for communication among researchers across all disciplines of parasitology, encompassing endoparasites, ectoparasites, transmission vectors, and susceptible hosts. Each monthly issue of Trends in Parasitology offers authoritative, cutting-edge, and yet accessible review articles, providing a balanced and comprehensive overview, along with opinion pieces offering personal and novel perspectives. Additionally, the journal publishes a variety of short articles designed to inform and stimulate thoughts in a lively and widely-accessible manner. These include Science & Society (discussing the interface between parasitology and the general public), Spotlight (highlighting recently published research articles), Forum (presenting single-point hypotheses), Parasite/Vector of the Month (featuring a modular display of the selected species), Letter (providing responses to recent articles in Trends in Parasitology), and Trendstalk (conducting interviews). Please note that the journal exclusively publishes literature reviews based on published data, with systematic reviews, meta-analysis, and unpublished primary research falling outside our scope.
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