Distinct metabolites in atherosclerosis based on metabolomics: A systematic review and meta-analysis primarily in Chinese population.

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2024-11-09 DOI:10.1016/j.numecd.2024.103789

Jinlin Tong, Xu Han, Yuanyuan Li, Yuyao Wang, Meijie Liu, Hong Liu, Jinghua Pan, Lei Zhang, Ying Liu, Miao Jiang, Hongyan Zhao

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Abstract

Aims: Atherosclerosis is a life-threatening disease that develops when a plaque builds up inside an artery and progresses silently. Identifying the early pathological changes and the biomarkers of atherosclerosis deserves attention. We aimed to systematically study and integrate the various metabolites of atherosclerosis in the level of disease to provide more evidences to support early prevention and treatment of atherosclerosis.

Data synthesis: The protocol was registered with PROPSERO (CRD42023441845). We searched 14,985 records via EMBASE, PubMed, Web of Science, WanFang data, VIP data, and CNKI databases. The collected metabolites were for qualitative and quantitative meta-analysis. The I² statistic estimated heterogeneity, with over 50 % considered to adopt the random-effects model. A total of 49 articles were included in the meta-analysis. We finally integrated 83 and 16 metabolites presented more than two times in inclusion studies, respectively in blood (plasma and serum) and urine. Among them, the level of citric acid (SMD = -10.35 [95%CI -15.03, -5.67], p < 0.001), lactic acid (SMD = 6.32 [95%CI 0.12, 12.52], p < 0.001) and TMAO (SMD = 1.40 [95%CI 0.27, 2.53], p < 0.001) had significant differences between atherosclerosis and controls. And we observed blood stasis syndrome of atherosclerosis patients present arterial ischemia and energy disorder obviously.

Conclusions: The study provides an in-depth understanding of the roles of metabolites on atherosclerosis progression and prediction primarily in Chinese population, which contributing to development of prevention and therapeutic potential in the future.

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基于代谢组学的动脉粥样硬化中的不同代谢物：主要针对中国人群的系统综述和荟萃分析

目的：动脉粥样硬化是一种危及生命的疾病，当斑块在动脉内形成并悄无声息地发展时就会发生。鉴别动脉粥样硬化的早期病理变化和生物标志物值得重视。我们旨在系统地研究和整合动脉粥样硬化在疾病层面的各种代谢物，为动脉粥样硬化的早期预防和治疗提供更多证据。数据综合：该协议在PROPSERO注册（CRD42023441845）。通过EMBASE、PubMed、Web of Science、万方数据、VIP数据、中国知网等数据库检索14985条记录。收集的代谢物进行定性和定量荟萃分析。I2统计量估计异质性，超过50%被认为采用随机效应模型。meta分析共纳入49篇文章。我们最终整合了83个和16个在纳入研究中出现两次以上的代谢物，分别在血液（血浆和血清）和尿液中。其中，柠檬酸水平（SMD = -10.35 [95%CI -15.03, -5.67], p）。结论：本研究主要在中国人群中深入了解代谢物在动脉粥样硬化进展和预测中的作用，有助于未来预防和治疗潜力的开发。

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来源期刊

Nutrition Metabolism and Cardiovascular Diseases 医学-内分泌学与代谢

CiteScore

6.80

自引率

2.60%

发文量

332

审稿时长

57 days

期刊介绍： Nutrition, Metabolism & Cardiovascular Diseases is a forum designed to focus on the powerful interplay between nutritional and metabolic alterations, and cardiovascular disorders. It aims to be a highly qualified tool to help refine strategies against the nutrition-related epidemics of metabolic and cardiovascular diseases. By presenting original clinical and experimental findings, it introduces readers and authors into a rapidly developing area of clinical and preventive medicine, including also vascular biology. Of particular concern are the origins, the mechanisms and the means to prevent and control diabetes, atherosclerosis, hypertension, and other nutrition-related diseases.