A Fusion Model of MRI Deep Transfer Learning and Radiomics for Discriminating between Pilocytic Astrocytoma and Adamantinomatous Craniopharyngioma.

IF 3.8 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Academic Radiology Pub Date : 2024-12-16 DOI:10.1016/j.acra.2024.11.044
Yu Mao, Xin Kong, Yuqi Luo, Fengjun Xi, Yan Li, Jun Ma
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Abstract

Rationale and objectives: This study aimed to develop and validate a fusion model combining MRI deep transfer learning (DTL) and radiomics for discriminating between pilocytic astrocytoma (PA) and adamantinomatous craniopharyngioma (ACP) in the sellar region.

Methods: This study included 348 patients with histologically confirmed PA (n = 139) and ACP (n = 209). Data were randomly divided into training and testing cohorts in a 7:3 ratio. Pre-trained ResNet50 network was utilized to extract DTL features from T1WI, T2WI, and CET1, while radiomics features (Rad) were extracted from manually delineated images of the same modalities. The fusion feature set (DLR) was constructed by integrating these features. Semantic features were used to develop clinical models. Pearson rank correlation and The least absolute shrinkage and selection operator regression were used for feature selection, and K-nearest neighbor algorithm was applied to establish the model. The performance of the model was evaluated using receiver operating characteristic curve. DeLong's test was performed to assess differences between models, and decision curve analysis was conducted to evaluate the clinical utility of the models.

Results: The DLR model achieved AUC values of 0.945 (95% CI, 0.9149-0.9760) in the training cohort and 0.929 (95% CI, 0.8824-0.9762) in the testing cohort, significantly higher than those of models using DTL features, Rad features, or clinical features alone.

Conclusion: The fusion model based on MRI deep transfer learning and radiomics (DLR) demonstrated high accuracy and clinical utility in discriminating between PA and ACP, providing an effective tool for the non-invasive diagnosis of these two diseases.

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来源期刊
Academic Radiology
Academic Radiology 医学-核医学
CiteScore
7.60
自引率
10.40%
发文量
432
审稿时长
18 days
期刊介绍: Academic Radiology publishes original reports of clinical and laboratory investigations in diagnostic imaging, the diagnostic use of radioactive isotopes, computed tomography, positron emission tomography, magnetic resonance imaging, ultrasound, digital subtraction angiography, image-guided interventions and related techniques. It also includes brief technical reports describing original observations, techniques, and instrumental developments; state-of-the-art reports on clinical issues, new technology and other topics of current medical importance; meta-analyses; scientific studies and opinions on radiologic education; and letters to the Editor.
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