Cu-MOF-based targeted nanomedicine utilizing biorthogonally catalyzed chemotherapy and chemodynamic therapy with spatiotemporal orchestration to treat hepatocellular carcinoma†

IF 4.2 2区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Chemical Communications Pub Date : 2024-12-03 Epub Date: 2024-12-19 DOI:10.1039/d4cc05890a
Xiuyan Wan , Yu Zhang , Huiwen Zhang , Wei Pan , Xincheng Qiao , Na Li , Bo Tang
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Abstract

A nanomedicine was developed using a Cu-based metal–organic framework (MOF) to co-deliver Cu(i) and prodrugs for targeted biorthogonally catalyzed chemotherapy and chemodynamic therapy of hepatocellular carcinoma.

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基于 Cu-MOF 的靶向纳米药物,利用生物催化化疗和时空协调的化学动力疗法治疗肝细胞癌
利用Cu基金属有机框架(MOF)开发了一种纳米药物,可将Cu(I)和前药共同递送,用于靶向生物正交催化肝癌化疗和化疗动力学治疗。
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来源期刊
Chemical Communications
Chemical Communications 化学-化学综合
CiteScore
8.60
自引率
4.10%
发文量
2705
审稿时长
1.4 months
期刊介绍: ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.
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