DKI and ¹H-MRS in angiogenesis evaluation of soft tissue sarcomas: a prospective clinical study based on MRI-pathology control method.

IF 3.2 3区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING BMC Medical Imaging Pub Date : 2024-12-18 DOI:10.1186/s12880-024-01526-8

Wubing Han, Cheng Xin, Zeguo Wang, Fei Wang, Yu Cheng, Xingrong Yang, Yangyun Zhou, Juntong Liu, Wanjiang Yu, Shaowu Wang

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Abstract

Background: The vascular endothelial growth factor (VEGF) and microvessel density (MVD) have been widely employed as angiogenesis indicators in the diagnosis and treatment of soft tissue sarcomas. While diffusion kurtosis imaging (DKI) and proton magnetic resonance spectroscopy (¹H-MRS) imaging hold potential in assessing angiogenesis in other tumors, their reliability in correlating with angiogenesis in soft tissue sarcomas remains uncertain, contingent upon accurately acquiring the region of interest (ROI).

Methods: 23 patients with soft tissue sarcomas (STSs) confirmed by pathology were selected, underwent DKI and ¹H-MRS at 3.0T MRI. The DKI parameters mean diffusivity (MD), mean kurtosis (MK), kurtosis anisotropy (KA), and ¹H-MRS parameters choline (Cho), lipid/lactate (LL) were measured by two radiologists. Two pathologists obtained pathological slices using a new sampling method called MRI-pathology control and evaluated VEGF and MVD in the selected regions. Correlations between MRI parameters and angiogenesis markers were assessed by Person or Spearman tests.

Results: The DKI parameters MD and KA, and the ¹H-MRS parameters Cho and LL, have varying degrees of correlation with the expression levels of VEGF and MVD. Among them, Cho exhibits the strongest correlation (r = 0.875, P < 0.001; r = 0.807, P < 0.001).

Conclusion: Based on this preliminary clinical studies, DKI and ¹H-MRS parameters are correlated with angiogenesis markers obtained through the "MRI-pathology control" method.

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DKI和1H-MRS在软组织肉瘤血管生成评价中的应用：基于mri病理对照方法的前瞻性临床研究

背景：血管内皮生长因子（VEGF）和微血管密度（MVD）作为血管生成指标已被广泛应用于软组织肉瘤的诊断和治疗。虽然扩散峰度成像（DKI）和质子磁共振波谱（1H-MRS）成像在评估其他肿瘤的血管生成方面具有潜力，但它们与软组织肉瘤血管生成相关的可靠性仍不确定，这取决于是否准确获取感兴趣区域（ROI）。方法：选择经病理证实的软组织肉瘤（STSs）患者23例，行DKI和1H-MRS 3.0T MRI检查。由2名放射科医生测量DKI参数平均扩散率（MD）、平均峰度（MK）、峰度各向异性（KA）和1H-MRS参数胆碱（Cho）、脂质/乳酸（LL）。两名病理学家使用一种称为mri病理对照的新采样方法获得病理切片，并评估选定区域的VEGF和MVD。通过Person或Spearman试验评估MRI参数与血管生成标志物之间的相关性。结果：DKI参数MD、KA和1H-MRS参数Cho、LL与VEGF、MVD的表达水平有不同程度的相关性。其中Cho相关性最强（r = 0.875， P）。结论：基于本初步临床研究，DKI、1H-MRS参数与“mri病理对照”法获得的血管生成标志物存在相关性。

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来源期刊

BMC Medical Imaging RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

4.60

自引率

3.70%

发文量

198

审稿时长

27 weeks

期刊介绍： BMC Medical Imaging is an open access journal publishing original peer-reviewed research articles in the development, evaluation, and use of imaging techniques and image processing tools to diagnose and manage disease.