Preoperative CT-based morphological heterogeneity for predicting survival in patients with colorectal cancer liver metastases after surgical resection: a retrospective study.

IF 3.2 3区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING BMC Medical Imaging Pub Date : 2024-12-18 DOI:10.1186/s12880-024-01524-w

Qian Xing, Yong Cui, Ming Liu, Xiao-Lei Gu, Xiao-Ting Li, Bao-Cai Xing, Ying-Shi Sun

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Abstract

Objective: To explore the value of preoperative CT-based morphological heterogeneity (MH) for predicting local tumor disease-free survival (LTDFS) and progression-free survival (PFS) in patients with colorectal cancer liver metastases (CRLM).

Methods: The latest CT data of 102 CRLM patients were retrospectively analyzed. The morphological score of each liver metastasis was obtained, and the morphological heterogeneity difference (MHD) was calculated. The receiver operating characteristic (ROC) curve was drawn, and the cutoff value was found. The Kaplan-Meier method was used to draw survival curves of patients with or without MH. The Cox regression analysis was used to build the model with MH and clinical characteristics for predicting PFS.

Results: In 78 patients without MH, median PFS was 9.0 months (95% CI:6.5-11.5), while in 24 patients with MH, median PFS was 6.0 months (95% CI:4.0-8.1), indicating that MH significantly affected PFS (p = 0.001). MH affected PFS in both the chemotherapy group and the chemotherapy combined with targeted therapy group (p = 0.005, p = 0.043). MH, preoperative carcinoembryonic antigen (CEA) and chemotherapy after surgery were independent predictors for postoperative PFS in patients with CRLM.

Conclusion: Preoperative CT-based MH had good efficacy for predicting LTDFS and PFS of CRLM patients after surgical resection, regardless of preoperative treatment. MH is one of the independent predictors of PFS.

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术前ct形态学异质性预测结直肠癌肝转移患者手术切除后生存：一项回顾性研究。

目的：探讨术前ct形态学异质性（MH）对大肠癌肝转移（CRLM）患者局部肿瘤无病生存期（LTDFS）和无进展生存期（PFS）的预测价值。方法：回顾性分析102例CRLM患者的最新CT资料。计算各肝转移灶的形态学评分，并计算形态学异质性差异（MHD）。绘制受试者工作特征（ROC）曲线，寻找截止值。采用Kaplan-Meier法绘制合并和未合并MH患者的生存曲线，采用Cox回归分析建立合并MH和临床特征的模型预测PFS。结果：78例无MH患者中，中位PFS为9.0个月（95% CI:6.5-11.5），而24例MH患者中位PFS为6.0个月（95% CI:4.0-8.1），表明MH显著影响PFS （p = 0.001）。化疗组和化疗联合靶向治疗组的MH均影响PFS （p = 0.005, p = 0.043）。MH、术前癌胚抗原（CEA）和术后化疗是CRLM患者术后PFS的独立预测因子。结论：术前ct为基础的MH预测CRLM患者手术切除后LTDFS和PFS均有较好的疗效，与术前治疗无关。MH是PFS的独立预测因子之一。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Medical Imaging RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

4.60

自引率

3.70%

发文量

198

审稿时长

27 weeks

期刊介绍： BMC Medical Imaging is an open access journal publishing original peer-reviewed research articles in the development, evaluation, and use of imaging techniques and image processing tools to diagnose and manage disease.