Association between triglyceride-glucose (TyG) index and the incidence of depression in US adults with diabetes or pre-diabetes

IF 4.2 2区医学 Q1 PSYCHIATRY Psychiatry Research Pub Date : 2025-02-01 DOI:10.1016/j.psychres.2024.116328

Pengfei Shi, Jianbang Fang, Chunyang Lou

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Abstract

Background

The relationship between the triglyceride glucose (TyG) index and the incidence of depression in populations with diabetes or pre-diabetes remains unclear. This study aims to investigate the association between the TyG index and depression incidence in diabetic/pre-diabetic populations.

Method

Data from the 2005–2018 National Health and Nutrition Examination Survey (NHANES) were analyzed. After adjustment for confounders, multivariate logistic regression models were fitted to investigate the association between TyG index and depression incidence. Restricted cubic splines (RCS), subgroup analysis, interaction analysis, and mediation analysis were also constructed.

Results

A total of 8,970 participants with diabetes or pre-diabetes were enrolled. The linear positive association between TyG index and the incidence of depression was observed. Insulin resistance partly mediates this association in mediation analysis. There is a U-shape association between TyG index and the incidence of depression in diabetic/pre-diabetic populations whose ethnicity is Other Hispanic (p for nonlinearity =0.0237). Subgroup analysis evaluated the robustness of our findings and interaction analysis showed that this association can be modified by race/ethnicity.

Conclusion

There is a linear positive association between the TyG index and the incidence of depression in populations with diabetes or pre-diabetes.

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甘油三酯-葡萄糖（TyG）指数与美国糖尿病或糖尿病前期成人抑郁症发病率之间的关系

背景：甘油三酯葡萄糖（TyG）指数与糖尿病或糖尿病前期人群抑郁发生率之间的关系尚不清楚。本研究旨在探讨糖尿病/糖尿病前期人群中TyG指数与抑郁症发病率之间的关系。方法：对2005-2018年全国健康与营养检查调查（NHANES）数据进行分析。校正混杂因素后，拟合多元logistic回归模型，探讨TyG指数与抑郁症发病率之间的关系。构建了限制性三次样条（RCS）、亚群分析、交互作用分析和中介分析。结果：共有8,970名糖尿病或糖尿病前期患者入组。TyG指数与抑郁发生率呈线性正相关。在中介分析中，胰岛素抵抗部分介导了这种关联。在其他西班牙裔的糖尿病/糖尿病前期人群中，TyG指数与抑郁症发病率呈u型相关（非线性p =0.0237）。亚组分析评估了我们研究结果的稳健性，相互作用分析表明这种关联可以被种族/民族所改变。结论：糖尿病或糖尿病前期人群中TyG指数与抑郁发生率呈线性正相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychiatry Research 医学-精神病学

CiteScore

17.40

自引率

1.80%

发文量

527

审稿时长

57 days

期刊介绍： Psychiatry Research offers swift publication of comprehensive research reports and reviews within the field of psychiatry. The scope of the journal encompasses: Biochemical, physiological, neuroanatomic, genetic, neurocognitive, and psychosocial determinants of psychiatric disorders. Diagnostic assessments of psychiatric disorders. Evaluations that pursue hypotheses about the cause or causes of psychiatric diseases. Evaluations of pharmacologic and non-pharmacologic psychiatric treatments. Basic neuroscience studies related to animal or neurochemical models for psychiatric disorders. Methodological advances, such as instrumentation, clinical scales, and assays directly applicable to psychiatric research.

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