Novel Genetic Loci Associated with PhenoAge Acceleration - Changzhou City, Jiangsu Province, China, 2012-2019.

IF 4.3 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH 中国疾病预防控制中心周报 Pub Date : 2024-12-06 DOI:10.46234/ccdcw2024.258

Yifan Wang, Yue Jiang, Hui Wang, Shuang Liang, Muhammed Lamin Sambou, Mei Wang, Meiqi Yang, Yakubu Salimata, Feifei Xu, Chenjie Li, Xiao Wang, Junpeng Yang, Meng Zhu, Cheng Wang, Guangfu Jin, Hongxia Ma, Honggang Yi, Hongbing Shen, Juncheng Dai

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Abstract

What is already known about this topic?: China is rapidly encountering population aging, yet studies on aging are limited by the traditional aging measure: chronological age, particularly in the field of genomics. Several promising aging measures have been proposed, but they lack comparative evaluation.

What is added by this report?: PhenoAge was identified as a measure of aging that demonstrated greater applicability in contemporary populations. Based on this, several novel genetic variants were found to enhance the predictive accuracy of aging.

What are the implications for public health practice?: These findings might provide new insights into aging and facilitate the development of a practical screening program based on PhenoAge, which aims to promote healthy aging in China.

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与表型加速相关的新基因位点——江苏省常州市，2012-2019。

关于这个话题我们已经知道了什么？中国正迅速面临人口老龄化问题，但对老龄化问题的研究却受到传统老龄化指标——实足年龄的限制，特别是在基因组学领域。提出了几种有前景的老化措施，但缺乏比较评价。这份报告增加了什么内容？表型年龄（PhenoAge）被认为是一种衡量衰老的指标，在当代人群中表现出更大的适用性。在此基础上，研究人员发现了一些新的基因变异，以提高衰老的预测准确性。这对公共卫生实践有什么影响？这些发现可能为研究衰老提供新的见解，并促进基于PhenoAge的实用筛查项目的发展，旨在促进中国的健康老龄化。

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中国疾病预防控制中心周报

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5.90

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