{"title":"Chemical inducers of proximity: precision tools for apoptosis in transcriptional regulation","authors":"Kai Huang","doi":"10.1038/s41392-024-02089-4","DOIUrl":null,"url":null,"abstract":"<p>A recent study published in <i>Science</i> by Sarott et al. introduces CDK-transcriptional/epigenetic chemical inducers of proximity (CDK-TCIPs), a novel therapeutic approach that reactivates pro-apoptotic genes to selectively kill BCL6-overexpressing lymphoid cancers. This gain-of-function strategy represents a significant advancement in targeting transcrptional dysregulation.<sup>1</sup></p>","PeriodicalId":21766,"journal":{"name":"Signal Transduction and Targeted Therapy","volume":"15 1","pages":""},"PeriodicalIF":40.8000,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Signal Transduction and Targeted Therapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41392-024-02089-4","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
A recent study published in Science by Sarott et al. introduces CDK-transcriptional/epigenetic chemical inducers of proximity (CDK-TCIPs), a novel therapeutic approach that reactivates pro-apoptotic genes to selectively kill BCL6-overexpressing lymphoid cancers. This gain-of-function strategy represents a significant advancement in targeting transcrptional dysregulation.1
期刊介绍：
Signal Transduction and Targeted Therapy is an open access journal that focuses on timely publication of cutting-edge discoveries and advancements in basic science and clinical research related to signal transduction and targeted therapy.
Scope: The journal covers research on major human diseases, including, but not limited to:
Cancer,Cardiovascular diseases,Autoimmune diseases,Nervous system diseases.
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