Synthesis and Properties of N,N′-Disubstituted Ureas and Their Isosteric Analogues Containing Polycyclic Fragments: XXI. N-(Adamantane-1-carbonyl]-N′-(haloaryl)selenoureas

Abstract

Selenoureas containing a halophenyl fragment were synthesized in 37–59% yields from adaman­tane-1-carbonyl isoselenocyanate and haloanilines. Replacement of the sulfur atom by selenium resulted in a reduction of the melting points of selenoureas by 8–47°C in comparison to their sulfur analogues. In silico screening showed that the most probable types of biological activity of the synthesized selenoureas are inhibition of human soluble epoxide hydrolase and anxiolytic activity.