{"title":"Drug-device-field integration for tumor therapeutic interference with home-tailored nano-heterojunctions","authors":"Yandai Lin, Xueli Ren, Fengqi Xuan, Zhe Liu","doi":"10.1007/s42114-024-01184-y","DOIUrl":null,"url":null,"abstract":"<div><p>Sonodynamic therapy has exhibited tremendous merits such as deep tissue penetration, minimal invasiveness, and neglectable side effects, but the strong O<sub>2</sub> dependence and complex tumor microenvironment limit the therapy efficiency. Herein, a type of BaTiO<sub>3</sub>@MnO<sub>2</sub>-based Z-scheme nano-heterojunction has been conjugated to doxorubicin-loaded carbon nanotubes to form functionalized hybrid nanocomposites for O<sub>2</sub>-independent and TME-modulating combinational tumor therapy. The existences of BaTiO<sub>3</sub> and MnO<sub>2</sub> afford a built-in microelectric field which induces band tilting to effectively transfer electrons with a Z-scheme track, prolonged the electron–hole separation lifetime, and maintained strong redox potentials for hydrolysis and abundant reactive oxygen species generation. The in vivo experiments prove that nano-heterojunctions actively accumulate at the tumor after intravenous injection and demonstrate a glutathione-responsive behavior to impair tumor anti-oxidant and enhance ROS contents. It was also noted that the ultrasound-mediated treatment in association with nano-heterojunctions showed a superior O<sub>2</sub>-independent tumor elimination (up to 90%) in company with dramatic recruitments of CD4<sup>+</sup> and CD8<sup>+</sup> T cells. Therefore, this study has validated the BaTiO<sub>3</sub>@MnO<sub>2</sub>-based Z-scheme nano-heterojunctions with tumor therapeutic interference in a drug-device-field integration manner and highlighted their promising utilities for modulating the tumor microenvironment and overcoming the O<sub>2</sub> dependence for an efficacious tumor therapy in live animals.</p></div>","PeriodicalId":7220,"journal":{"name":"Advanced Composites and Hybrid Materials","volume":"8 1","pages":""},"PeriodicalIF":23.2000,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Composites and Hybrid Materials","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1007/s42114-024-01184-y","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, COMPOSITES","Score":null,"Total":0}
引用次数: 0
Abstract
Sonodynamic therapy has exhibited tremendous merits such as deep tissue penetration, minimal invasiveness, and neglectable side effects, but the strong O2 dependence and complex tumor microenvironment limit the therapy efficiency. Herein, a type of BaTiO3@MnO2-based Z-scheme nano-heterojunction has been conjugated to doxorubicin-loaded carbon nanotubes to form functionalized hybrid nanocomposites for O2-independent and TME-modulating combinational tumor therapy. The existences of BaTiO3 and MnO2 afford a built-in microelectric field which induces band tilting to effectively transfer electrons with a Z-scheme track, prolonged the electron–hole separation lifetime, and maintained strong redox potentials for hydrolysis and abundant reactive oxygen species generation. The in vivo experiments prove that nano-heterojunctions actively accumulate at the tumor after intravenous injection and demonstrate a glutathione-responsive behavior to impair tumor anti-oxidant and enhance ROS contents. It was also noted that the ultrasound-mediated treatment in association with nano-heterojunctions showed a superior O2-independent tumor elimination (up to 90%) in company with dramatic recruitments of CD4+ and CD8+ T cells. Therefore, this study has validated the BaTiO3@MnO2-based Z-scheme nano-heterojunctions with tumor therapeutic interference in a drug-device-field integration manner and highlighted their promising utilities for modulating the tumor microenvironment and overcoming the O2 dependence for an efficacious tumor therapy in live animals.
期刊介绍：
Advanced Composites and Hybrid Materials is a leading international journal that promotes interdisciplinary collaboration among materials scientists, engineers, chemists, biologists, and physicists working on composites, including nanocomposites. Our aim is to facilitate rapid scientific communication in this field.
The journal publishes high-quality research on various aspects of composite materials, including materials design, surface and interface science/engineering, manufacturing, structure control, property design, device fabrication, and other applications. We also welcome simulation and modeling studies that are relevant to composites. Additionally, papers focusing on the relationship between fillers and the matrix are of particular interest.
Our scope includes polymer, metal, and ceramic matrices, with a special emphasis on reviews and meta-analyses related to materials selection. We cover a wide range of topics, including transport properties, strategies for controlling interfaces and composition distribution, bottom-up assembly of nanocomposites, highly porous and high-density composites, electronic structure design, materials synergisms, and thermoelectric materials.
Advanced Composites and Hybrid Materials follows a rigorous single-blind peer-review process to ensure the quality and integrity of the published work.
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