Correction to “The Effect of Low-Dose Colchicine on the Phenotype and Function of Neutrophils and Monocytes in Patients with Chronic Coronary Artery Disease: A Double-Blind Randomized Placebo-Controlled Cross-over Study”

Abstract

Tercan, H. et al. The effect of low-dose colchicine on the phenotype and function of neutrophils and monocytes in patients with chronic coronary artery disease: a double-blind randomized placebo-controlled cross-over study. Clin. Pharmacol. Ther. 116, 1325–1333 (2024).

In the article cited above, we have determined that the Results section on page 1327 (“The effect of colchicine on NET formation and ROS production”) is incorrect.

The original version states, “We quantified the amount of DNA released during NOX-dependent and -independent NET formation assays. We did not find any differences in the amount of DNA released in either assay or various stimuli used comparing placebo and colchicine-treated neutrophils (Table S7).”

However, Table S7 mentions that the P-value of TRAP-6 stimulated platelets (a NOX-independent stimulus) is 0.01.

The sentence above in the Results section (page 1327) should read: “We quantified the amount of DNA released during NOX-dependent and -independent NET formation assays. DNA release upon stimulation by TRAP-6 stimulated platelets was significantly higher after colchicine treatment. We did not find further differences in the rest of the stimuli used.”

In the Discussion, we stated “Formation of NETs is an important function of neutrophils which facilitates trapping extracellular pathogens as well as wound healing. However, NETs can also contribute to atherosclerosis pathophysiology. We assessed the NET formation capacity of neutrophils with NOX-dependent and independent NET-inducing stimuli. NOX-dependent NET formation capacity remained unaltered after either of the treatment periods.” Thus, this section remains correct.

The authors apologize for the error.