Lipid-Lowering Therapy Associated Erectile Dysfunction and Testicular Pain: A Rare Case Report.

IF 0.8 Q4 PHARMACOLOGY & PHARMACY Hospital Pharmacy Pub Date : 2024-12-17 DOI:10.1177/00185787241303994
Manjappa Mahadevappa, Sakeer Hussain, Sachin Dharwadkhar, Kevin Jose Madapat
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Abstract

Lipid-lowering therapy (LLT) includes a diverse group of pharmaceuticals designed to reduce blood levels of cholesterol and triglyceride (TG), helping to prevent cardiovascular diseases like myocardial infarction and stroke. LLT includes treatment with several lipid-lowering drugs (LLD), including hydroxymethylglutaryl (HMG-CoA) reductase inhibitors (statin), PCSK9 Inhibitors, cholesterol-absorbing inhibitors (Ezetimibe), Bile Acid Sequestrants, Fibrates, Niacin (Vitamin B3), Omega-3 Fatty Acids, Bempedoic Acid, and combination therapy. The efficacy and safety of these molecules vary widely. Statins are the first-line LLD for treating hypercholesterolemia and are widely used for cardiovascular disease prevention. Common side effects include muscle-related issues such as myalgia, muscle atrophy, and, rarely, rhabdomyolysis. However, adverse effects on male reproductive health are infrequent and often underreported. Other medication classes employed in LLT mostly share many of the ADRs seen with statins, although individual classes may have unique ADRs depending on the pharmacokinetics and pharmacodynamics. Here, we are reporting a unique case of a 50-year-old male patient with no prior history of sexual dysfunction or testicular issues and other comorbidities or habits, who developed loss of libido, erectile dysfunction (ED) and testicular pain with most of the LLD, which promptly resolved on discontinuation of the LLT. This case highlights the importance of considering potential reproductive side effects when prescribing LLT and monitoring male patients for symptoms of sexual dysfunction.

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降脂治疗相关的勃起功能障碍和睾丸疼痛:一个罕见的病例报告。
降脂疗法(LLT)包括一组不同的药物,旨在降低血液中的胆固醇和甘油三酯(TG)水平,帮助预防心血管疾病,如心肌梗死和中风。LLT包括几种降脂药物(LLD)的治疗,包括羟甲基戊二酰(HMG-CoA)还原酶抑制剂(他汀类)、PCSK9抑制剂、胆固醇吸收抑制剂(依折替米贝)、胆汁酸螯合剂、贝特酸、烟酸(维生素B3)、Omega-3脂肪酸、苯甲多酸和联合治疗。这些分子的功效和安全性差别很大。他汀类药物是治疗高胆固醇血症的一线LLD,广泛用于心血管疾病的预防。常见的副作用包括肌肉相关问题,如肌痛、肌肉萎缩,以及很少发生的横纹肌溶解。然而,对男性生殖健康的不利影响并不常见,而且往往报告不足。LLT中使用的其他药物类别大多与他汀类药物有许多共同的adr,尽管根据药代动力学和药效学,个别类别可能有独特的adr。在这里,我们报告一个独特的病例,一个50岁的男性患者,以前没有性功能障碍或睾丸问题的历史和其他合并症或习惯,谁发展性欲丧失,勃起功能障碍(ED)和睾丸疼痛与大多数LLD,并立即解决了终止LLT。本病例强调了在处方LLT和监测男性患者性功能障碍症状时考虑潜在生殖副作用的重要性。
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来源期刊
Hospital Pharmacy
Hospital Pharmacy PHARMACOLOGY & PHARMACY-
CiteScore
1.70
自引率
0.00%
发文量
63
期刊介绍: Hospital Pharmacy is a monthly peer-reviewed journal that is read by pharmacists and other providers practicing in the inpatient and outpatient setting within hospitals, long-term care facilities, home care, and other health-system settings The Hospital Pharmacy Assistant Editor, Michael R. Cohen, RPh, MS, DSc, FASHP, is author of a Medication Error Report Analysis and founder of The Institute for Safe Medication Practices (ISMP), a nonprofit organization that provides education about adverse drug events and their prevention.
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