Decreased brain function and anxiety-related loops in harm-avoidance personality: a resting-state functional magnetic resonance imaging study.

IF 3.5 3区医学 Q2 NEUROSCIENCES Brain Research Bulletin Pub Date : 2024-12-17 DOI:10.1016/j.brainresbull.2024.111174

Jiaqi Wen, Tao Guo, Jingjing Xu, Xiaojie Duanmu, Sijia Tan, Minming Zhang, Xiaojun Xu, Xiaojun Guan

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引用次数: 0

Abstract

Background: Personality is a unique and relatively stable psychological concept that defines individual human beings. It strongly influences long-term behavioral styles such as emotional expression. This study aims to elucidate the brain functional underpinning behind personality.

Methods: A total of 97 young subjects were included. All subjects completed personality, emotion, and cognition scales, and resting-state functional magnetic resonance imaging scan. All subjects were divided into subtypes of harm avoidance (HA) and reward dependence (RD) by clustering analysis. Graph theory analysis and network-based analysis were used to explore the brain functional configurations of personalities.

Results: HA subjects showed lower network metrics (P = 0.018) and node metrics (P < 0.009). A negative component network was observed in HA subjects (P < 0.001). Functional topology metrics were negatively correlated with the HA score. The amygdala-IPG functional connectivity mediated the positive correlation between personality HA and state anxiety.

Conclusion: Personality HA is associated with decreased functional configuration, which could influence emotion by downregulating amygdala-IPG coupling. These findings provide insight into how the brain shapes personality and related emotions.

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来源期刊

Brain Research Bulletin 医学-神经科学

CiteScore

6.90

自引率

2.60%

发文量

253

审稿时长

67 days

期刊介绍： The Brain Research Bulletin (BRB) aims to publish novel work that advances our knowledge of molecular and cellular mechanisms that underlie neural network properties associated with behavior, cognition and other brain functions during neurodevelopment and in the adult. Although clinical research is out of the Journal''s scope, the BRB also aims to publish translation research that provides insight into biological mechanisms and processes associated with neurodegeneration mechanisms, neurological diseases and neuropsychiatric disorders. The Journal is especially interested in research using novel methodologies, such as optogenetics, multielectrode array recordings and life imaging in wild-type and genetically-modified animal models, with the goal to advance our understanding of how neurons, glia and networks function in vivo.