Weak brain function and anxiety-related loop in harm-avoidance personality: A resting-state functional magnetic resonance imaging study

IF 3.7 3区医学 Q2 NEUROSCIENCES Brain Research Bulletin Pub Date : 2025-01-01 DOI:10.1016/j.brainresbull.2024.111174

Jiaqi Wen , Tao Guo , Jingjing Xu , Xiaojie Duanmu , Sijia Tan , Minming Zhang , Xiaojun Xu , Xiaojun Guan

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Abstract

Background

Personality is a unique and relatively stable psychological concept that defines individual human beings. It strongly influences long-term behavioral styles such as emotional expression. This study aims to elucidate the brain functional underpinning behind personality.

Methods

A total of 97 young subjects were included. All subjects completed personality, emotion, and cognition scales, and resting-state functional magnetic resonance imaging scan. All subjects were divided into subtypes of harm avoidance (HA) and reward dependence (RD) by clustering analysis. Graph theory analysis and network-based analysis were used to explore the brain functional configurations of personalities.

Results

HA subjects showed lower network metrics (P = 0.018) and node metrics (P < 0.009). A negative component network was observed in HA subjects (P < 0.001). Functional topology metrics were negatively correlated with the HA score. The amygdala-IPG functional connectivity mediated the positive correlation between personality HA and state anxiety.

Conclusion

Personality HA is associated with decreased functional configuration, which could influence emotion by downregulating amygdala-IPG coupling. These findings provide insight into how the brain shapes personality and related emotions.

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伤害回避型人格的大脑功能下降和焦虑相关回路：静息态功能磁共振成像研究。

背景：人格是定义个体的独特而相对稳定的心理概念。它强烈地影响着长期的行为风格，比如情绪表达。本研究旨在阐明人格背后的脑功能基础。方法：共纳入97名青年受试者。所有受试者完成人格、情绪、认知量表和静息状态功能磁共振成像扫描。聚类分析将被试分为伤害回避型（HA）和奖励依赖型（RD）。采用图论分析和基于网络的分析来探讨人格的脑功能配置。结果：HA组的网络指标（P = 0.018）和节点指标（P < 0.009）较低。HA组存在负成分网络（P < 0.001）。功能拓扑指标与HA评分呈负相关。杏仁核- ipg功能连通性介导人格HA与状态焦虑的正相关。结论：人格HA与功能构型下降有关，其可能通过下调杏仁核- ipg耦合来影响情绪。这些发现让我们深入了解大脑是如何塑造个性和相关情绪的。

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来源期刊

Brain Research Bulletin 医学-神经科学

CiteScore

6.90

自引率

2.60%

发文量

253

审稿时长

67 days

期刊介绍： The Brain Research Bulletin (BRB) aims to publish novel work that advances our knowledge of molecular and cellular mechanisms that underlie neural network properties associated with behavior, cognition and other brain functions during neurodevelopment and in the adult. Although clinical research is out of the Journal''s scope, the BRB also aims to publish translation research that provides insight into biological mechanisms and processes associated with neurodegeneration mechanisms, neurological diseases and neuropsychiatric disorders. The Journal is especially interested in research using novel methodologies, such as optogenetics, multielectrode array recordings and life imaging in wild-type and genetically-modified animal models, with the goal to advance our understanding of how neurons, glia and networks function in vivo.