Systematically-designed mixtures outperform single fibers for gut microbiota support.

IF 12.2 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Gut Microbes Pub Date : 2025-12-01 Epub Date: 2024-12-20 DOI:10.1080/19490976.2024.2442521
T M Cantu-Jungles, V Agamennone, T J Van den Broek, F H J Schuren, B Hamaker
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Abstract

Dietary fiber interventions to modulate the gut microbiota have largely relied on isolated fibers or specific fiber sources. We hypothesized that fibers systematically blended could promote more health-related bacterial groups. Initially, pooled in vitro fecal fermentations were used to design dietary fiber mixtures to support complementary microbial groups related to health. Then, microbial responses were compared for the designed mixtures versus their single fiber components in vitro using fecal samples from a separate cohort of 10 healthy adults. The designed fiber mixtures outperformed individual fibers in supporting bacterial taxa across donors resulting in superior alpha diversity and unexpected higher SCFA production. Moreover, unique shifts in community structure and specific taxa were observed for fiber mixtures that were not observed for single fibers, suggesting a synergistic effect when certain fibers are put together. Fiber mixture responses were remarkably more consistent than individual fibers across donors in promoting several taxa, especially butyrate producers from the Clostridium cluster XIVa. This is the first demonstration of synergistic fiber interactions for superior support of a diverse group of important beneficial microbes consistent across people, and unexpectedly high SCFA production. Overall, harnessing the synergistic potential of designed fiber mixtures represents a promising and more efficacious avenue for future prebiotic development.

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系统设计的混合物在支持肠道微生物群方面优于单一纤维。
调节肠道微生物群的膳食纤维干预措施主要依赖于孤立的纤维或特定的纤维来源。我们假设,系统地混合纤维可以促进更多与健康相关的细菌群。最初,我们利用体外粪便发酵来设计膳食纤维混合物,以支持与健康相关的互补微生物群。然后,利用 10 名健康成年人的粪便样本,比较了设计的混合物与单一纤维成分在体外的微生物反应。设计的纤维混合物在支持各供体细菌分类群方面的表现优于单个纤维,从而产生了卓越的α多样性和意想不到的更高SCFA产量。此外,在纤维混合物中观察到了群落结构和特定分类群的独特变化,而在单一纤维中没有观察到这种变化,这表明当某些纤维组合在一起时会产生协同效应。在促进多个分类群,特别是梭状芽孢杆菌 XIVa 群的丁酸盐生产者方面,不同供体的纤维混合物反应比单个纤维反应更加一致。这是首次展示纤维之间的协同作用,可为不同人群的多种重要有益微生物提供卓越支持,并产生意想不到的高 SCFA。总之,利用设计纤维混合物的协同潜力是未来益生元开发的一条前景广阔、更有效的途径。
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来源期刊
Gut Microbes
Gut Microbes Medicine-Microbiology (medical)
CiteScore
18.20
自引率
3.30%
发文量
196
审稿时长
10 weeks
期刊介绍: The intestinal microbiota plays a crucial role in human physiology, influencing various aspects of health and disease such as nutrition, obesity, brain function, allergic responses, immunity, inflammatory bowel disease, irritable bowel syndrome, cancer development, cardiac disease, liver disease, and more. Gut Microbes serves as a platform for showcasing and discussing state-of-the-art research related to the microorganisms present in the intestine. The journal emphasizes mechanistic and cause-and-effect studies. Additionally, it has a counterpart, Gut Microbes Reports, which places a greater focus on emerging topics and comparative and incremental studies.
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