Correlation between hematological indicators in acclimatized high-altitude individuals and acute mountain sickness.

IF 2.3 3区 生物学 Q2 MULTIDISCIPLINARY SCIENCES PeerJ Pub Date : 2024-12-16 eCollection Date: 2024-01-01 DOI:10.7717/peerj.18738
Zhicai Li, Jun Xiao, Cuiying Li, Xiaowei Li, Daoju Ren
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Abstract

Background: The impact of acute mountain sickness (AMS) on individuals ascending to plateaus, soon after exposure to high altitudes, is well-documented. However, the specific relationship between AMS and alterations in blood parameters remains unclear.

Methods: A total of 40 healthy volunteers were recruited. Following their arrival at an altitude of 3,300 m, an AMS questionnaire survey was administered 48 h later. Based on the AMS scores obtained, participants were categorized into three groups: non-AMS, mild AMS, and moderate/severe AMS (encompassing both moderate and severe cases). Blood routine tests were performed on all groups at 3-, 7-, and 30-days post-arrival at the plateau, with blood oxygen saturation tests conducted at 3 and 30 days after rapidly entering the plateau.

Results: In the current investigation, a total of 40 participants were stratified into non-AMS (n = 24), mild-AMS (n = 8), and moderate/severe-AMS (n = 8) cohorts subsequent to rapid ascension to an altitude of 3,300 m. The incidence of AMS in this study was 40%. Noteworthy elevations in red blood cells (RBC), hemoglobin (Hb), and hematocrit (HCT) levels were noted at the 3-day mark post-ascent across all delineated groups. By the 7th day, the moderate/severe-AMS cohort displayed sustained increments in Hb and HCT levels, whereas solely HCT levels rose in the mild-AMS and non-AMS cohorts. Upon reaching the 30-day milestone, the moderate/severe-AMS group demonstrated a reduction in RBC, Hb, and HCT levels, while only HCT levels decreased in the mild-AMS and non-AMS groups. Furthermore, it was observed that all groups exhibited notable reductions in oxygen saturation (SpO2) at 3 days post-ascent, followed by a partial recovery at 30 days, albeit remaining below baseline levels. The correlation analysis results indicated that RBC, Hb, and HCT exhibited a positive correlation with the severity of AMS after a 7-day acclimatization period at high altitude. Conversely, SpO2 demonstrated a negative correlation with the severity of AMS following the same duration at high altitude. The findings of the study suggest a strong association between alterations in RBC, Hb, and HCT levels and AMS, particularly among individuals in the moderate/severe-AMS category who displayed more significant fluctuations in these parameters.

Conclusion: Individuals suffering from moderate to severe AMS demonstrated increased levels of RBC, Hb, and HCT, as well as reduced SpO2, indicating a greater need for oxygen adaptation to high-altitude hypoxia. These findings emphasize the physiological adjustments to high altitudes and their potential implications for the treatment of AMS.

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来源期刊
PeerJ
PeerJ MULTIDISCIPLINARY SCIENCES-
CiteScore
4.70
自引率
3.70%
发文量
1665
审稿时长
10 weeks
期刊介绍: PeerJ is an open access peer-reviewed scientific journal covering research in the biological and medical sciences. At PeerJ, authors take out a lifetime publication plan (for as little as $99) which allows them to publish articles in the journal for free, forever. PeerJ has 5 Nobel Prize Winners on the Board; they have won several industry and media awards; and they are widely recognized as being one of the most interesting recent developments in academic publishing.
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