Prabu Velumani, Naveen Palani, A. Antalin Casmie, Rajeswari Senthilvel, Vijaya Parthasarthy
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引用次数: 0
Abstract
The widespread use of nanoparticles raises substantial environmental, health, and safety issues. The specific mechanisms by which they impact plants and animals, as well as the entire scope of their possible impact, are still unknown. The current work investigates the impact of varying CuO NPs concentrations on phytotoxicity, cytotoxicity, genotoxicity, and antioxidant activity. Exposure of Mung bean seeds to CuO NPs results in the uptake of these particles by the roots and their subsequent transportation to various plant components, including the root, stem, and leaf. This uptake of CuO NPs triggers the production of reactive oxygen species (ROS). The CuO NPs can induce toxicological consequences due to their heightened propensity to produce excessive amounts of ROS. The absorption of CuO NPs might cause deformation and disintegration of the erythrocyte membrane, resulting in cell rupture due to osmotic pressure. The Allium cepa cytotoxicity study aimed to examine the harmful effects of CuO NPs and assess their impact on cellular structures at a microscopic scale. This work aims to analyze the cellular interaction of CuO NPs by measuring the Mitotic Index (MI) in the root cells of Allium cepa. The CuO NPs rapidly interact with plant and human cells, as well as chromosomes, leading to nano-phytotoxicity, nano-cytotoxicity, and nano-genotoxicity.
期刊介绍：
Toxicology in Vitro publishes original research papers and reviews on the application and use of in vitro systems for assessing or predicting the toxic effects of chemicals and elucidating their mechanisms of action. These in vitro techniques include utilizing cell or tissue cultures, isolated cells, tissue slices, subcellular fractions, transgenic cell cultures, and cells from transgenic organisms, as well as in silico modelling. The Journal will focus on investigations that involve the development and validation of new in vitro methods, e.g. for prediction of toxic effects based on traditional and in silico modelling; on the use of methods in high-throughput toxicology and pharmacology; elucidation of mechanisms of toxic action; the application of genomics, transcriptomics and proteomics in toxicology, as well as on comparative studies that characterise the relationship between in vitro and in vivo findings. The Journal strongly encourages the submission of manuscripts that focus on the development of in vitro methods, their practical applications and regulatory use (e.g. in the areas of food components cosmetics, pharmaceuticals, pesticides, and industrial chemicals). Toxicology in Vitro discourages papers that record reporting on toxicological effects from materials, such as plant extracts or herbal medicines, that have not been chemically characterized.
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