{"title":"Unveiling the hidden network of STING's subcellular regulation.","authors":"Xiaoqi Sun, Brian D Brown","doi":"10.1016/j.cels.2024.11.014","DOIUrl":null,"url":null,"abstract":"<p><p>A new study deconvolutes the systems-level control of the cGAS-STING pathway and identifies many novel regulators of STING biology. This was made possible by optical pooled screening (OPS), which enables high-dimensional imaging of millions of gene-edited cells, showcasing the future of CRISPR screening.</p>","PeriodicalId":93929,"journal":{"name":"Cell systems","volume":"15 12","pages":"1153-1155"},"PeriodicalIF":0.0000,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell systems","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.cels.2024.11.014","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
A new study deconvolutes the systems-level control of the cGAS-STING pathway and identifies many novel regulators of STING biology. This was made possible by optical pooled screening (OPS), which enables high-dimensional imaging of millions of gene-edited cells, showcasing the future of CRISPR screening.
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