Tuberculosis molecular bacterial load assay in the management of tuberculosis.

IF 3.6 3区 医学 Q2 INFECTIOUS DISEASES Current Opinion in Infectious Diseases Pub Date : 2024-12-18 DOI:10.1097/QCO.0000000000001084
Stephen H Gillespie, Wilber Sabiiti
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Abstract

Purpose of review: Treatment monitoring remains a challenge in tuberculosis. The development of the tuberculosis molecular bacterial load assay (TB-MBLA) opens the possibility of real-time treatment monitoring. This review summarizes recent TB-MBLA research and outlines a future research agenda.

Recent findings: Recent studies show that TB-MBLA can be applied a wide range of specimens to make a quantitative assessment of the number live M. tuberculosis organisms rapidly. This allows real-time monitoring of treatment response that simplifies patient management and facilitates comparison of different treatment regimens.

Summary: The ability to measure the number of live organisms in real-time could improve treatment outcome. The TB-MBLA should revolutionize our understanding of the pathology of tuberculosis with significant implications for clinical practice and research.

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审查目的:治疗监测仍是结核病治疗中的一项挑战。结核病分子细菌负荷测定(TB-MBLA)的开发为实时治疗监测提供了可能。本综述总结了最近的 TB-MBLA 研究,并概述了未来的研究议程:最近的研究表明,TB-MBLA 可以应用于多种标本,快速定量评估活结核杆菌的数量。小结:实时测量活菌数量的能力可改善治疗效果。TB-MBLA 将彻底改变我们对结核病病理的认识,并对临床实践和研究产生重大影响。
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来源期刊
CiteScore
6.70
自引率
2.60%
发文量
121
审稿时长
6-12 weeks
期刊介绍: This reader-friendly, bimonthly resource provides a powerful, broad-based perspective on the most important advances from throughout the world literature. Featuring renowned guest editors and focusing exclusively on two topics, every issue of Current Opinion in Infectious Disease delivers unvarnished, expert assessments of developments from the previous year. Insightful editorials and on-the-mark invited reviews cover key subjects such as HIV infection and AIDS; skin and soft tissue infections; respiratory infections; paediatric and neonatal infections; gastrointestinal infections; tropical and travel-associated diseases; and antimicrobial agents.
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