{"title":"Metabolic engineering of microorganisms for carbon dioxide utilization.","authors":"Jeageon Lee, Hye Eun Yu, Sang Yup Lee","doi":"10.1016/j.copbio.2024.103244","DOIUrl":null,"url":null,"abstract":"<p><p>The escalating climate crisis underscores the urgent need for sustainable development, with CO<sub>2</sub> utilization emerging as a pivotal approach to mitigating greenhouse gas emissions. Among various technological approaches, metabolic engineering of microorganisms for CO<sub>2</sub> utilization offers significant potential. This review covers the engineering of endogenous CO<sub>2</sub> fixation pathways, the construction of novel synthetic pathways, and strategies to optimize metabolic flux, enhance cofactor availability, and manipulate regulatory genes to improve CO<sub>2</sub> assimilation efficiency. It also explores the roles of evolutionary engineering, enzyme engineering, and CO<sub>2</sub> concentrating mechanisms in improving CO<sub>2</sub> fixation. Additionally, the review underscores advancements in converting CO<sub>2</sub> into valuable products such as biofuels, bioplastics, and chemicals using both native and synthetic autotrophic microorganisms.</p>","PeriodicalId":10833,"journal":{"name":"Current opinion in biotechnology","volume":"91 ","pages":"103244"},"PeriodicalIF":7.1000,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current opinion in biotechnology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1016/j.copbio.2024.103244","RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
引用次数: 0
Abstract
The escalating climate crisis underscores the urgent need for sustainable development, with CO2 utilization emerging as a pivotal approach to mitigating greenhouse gas emissions. Among various technological approaches, metabolic engineering of microorganisms for CO2 utilization offers significant potential. This review covers the engineering of endogenous CO2 fixation pathways, the construction of novel synthetic pathways, and strategies to optimize metabolic flux, enhance cofactor availability, and manipulate regulatory genes to improve CO2 assimilation efficiency. It also explores the roles of evolutionary engineering, enzyme engineering, and CO2 concentrating mechanisms in improving CO2 fixation. Additionally, the review underscores advancements in converting CO2 into valuable products such as biofuels, bioplastics, and chemicals using both native and synthetic autotrophic microorganisms.
期刊介绍：
Current Opinion in Biotechnology (COBIOT) is renowned for publishing authoritative, comprehensive, and systematic reviews. By offering clear and readable syntheses of current advances in biotechnology, COBIOT assists specialists in staying updated on the latest developments in the field. Expert authors annotate the most noteworthy papers from the vast array of information available today, providing readers with valuable insights and saving them time.
As part of the Current Opinion and Research (CO+RE) suite of journals, COBIOT is accompanied by the open-access primary research journal, Current Research in Biotechnology (CRBIOT). Leveraging the editorial excellence, high impact, and global reach of the Current Opinion legacy, CO+RE journals ensure they are widely read resources integral to scientists' workflows.
COBIOT is organized into themed sections, each reviewed once a year. These themes cover various areas of biotechnology, including analytical biotechnology, plant biotechnology, food biotechnology, energy biotechnology, environmental biotechnology, systems biology, nanobiotechnology, tissue, cell, and pathway engineering, chemical biotechnology, and pharmaceutical biotechnology.
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