Yu-Peng Li , Ying Li , Wen-Jing Gao , Chu-Hong Fang , Ming-Jun Lv , Jian-Min Yue , Jin-Hai Yu
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引用次数: 0
Abstract
A phytochemical investigation into the plants of Euphorbia esula L. has yielded 19 diterpenoids, comprising 17 jatrophane-type (1−7 and 9−18) and two ingenane-type (8 and 19). The structures of these compounds were elucidated by a combination of spectrum elucidations, quantum chemical calculations, and X-ray single crystal diffraction. Biological evaluations demonstrated that compounds 6, 8, 18, and 19 show significant anti-inflammatory activity with IC50 values within 10 μM, without displaying any morphological signs of cytotoxicity. Further biological analysis revealed that euphoresulin A (8) is involved in the suppression of inflammatory response by blocking the activation of NF-κB/MAPK and activating Nrf2/HO-1 singling pathways.
期刊介绍：
Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.
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