Deep learning radiomics nomograms predict Isocitrate dehydrogenase (IDH) genotypes in brain glioma: A multicenter study.

IF 2.1 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Magnetic resonance imaging Pub Date : 2024-12-19 DOI:10.1016/j.mri.2024.110314
Darui Li, Wanjun Hu, Laiyang Ma, Wenxia Yang, Yang Liu, Jie Zou, Xin Ge, Yuping Han, Tiejun Gan, Dan Cheng, Kai Ai, Guangyao Liu, Jing Zhang
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引用次数: 0

Abstract

Purpose: To explore the feasibility of Deep learning radiomics nomograms (DLRN) in predicting IDH genotype.

Methods: A total of 402 glioma patients from two independent centers were retrospectively included, and the data from center I was randomly divided into a training cohort (n = 239) and an internal validation cohort (n = 103) on a 7:3 basis. Center II served as an independent external validation cohort (n = 60). We developed a DLRN for IDH classification of gliomas based on T2 images. This hybrid model integrates deep learning features, radiomics features, and clinical features most relevant to IDH genotypes and finally classifies them using multivariate logistic regression analysis. We used the area under the curve (AUC) of the receiver operating characteristic (ROC) to evaluate the performance of the model and applied the DLRN score to the survival analysis of some of the follow-up glioma patients.

Results: The proposed model had an area under the curve (AUC) of 0.98 in an externally validated cohort, and DLRN scores were significantly associated with the overall survival of glioma patients.

Conclusions: Deep learning radiomics nomograms performed well in non-invasively predicting IDH mutation status in gliomas, assisting stratified management and targeted therapy for glioma patients.

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来源期刊
Magnetic resonance imaging
Magnetic resonance imaging 医学-核医学
CiteScore
4.70
自引率
4.00%
发文量
194
审稿时长
83 days
期刊介绍: Magnetic Resonance Imaging (MRI) is the first international multidisciplinary journal encompassing physical, life, and clinical science investigations as they relate to the development and use of magnetic resonance imaging. MRI is dedicated to both basic research, technological innovation and applications, providing a single forum for communication among radiologists, physicists, chemists, biochemists, biologists, engineers, internists, pathologists, physiologists, computer scientists, and mathematicians.
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