Deep learning radiomics nomograms predict Isocitrate dehydrogenase (IDH) genotypes in brain glioma: A multicenter study

Abstract

Purpose

To explore the feasibility of Deep learning radiomics nomograms (DLRN) in predicting IDH genotype.

Methods

A total of 402 glioma patients from two independent centers were retrospectively included, and the data from center I was randomly divided into a training cohort (n = 239) and an internal validation cohort (n = 103) on a 7:3 basis. Center II served as an independent external validation cohort (n = 60). We developed a DLRN for IDH classification of gliomas based on T2 images. This hybrid model integrates deep learning features, radiomics features, and clinical features most relevant to IDH genotypes and finally classifies them using multivariate logistic regression analysis. We used the area under the curve (AUC) of the receiver operating characteristic (ROC) to evaluate the performance of the model and applied the DLRN score to the survival analysis of some of the follow-up glioma patients.

Results

The proposed model had an area under the curve (AUC) of 0.98 in an externally validated cohort, and DLRN scores were significantly associated with the overall survival of glioma patients.

Conclusions

Deep learning radiomics nomograms performed well in non-invasively predicting IDH mutation status in gliomas, assisting stratified management and targeted therapy for glioma patients.