The effect of micro-vessel viscosity on the resonance response of a two-microbubble system

IF 3.8 2区 物理与天体物理 Q1 ACOUSTICS Ultrasonics Pub Date : 2024-12-17 DOI:10.1016/j.ultras.2024.107558
Hossein Yusefi , Brandon Helfield
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Abstract

Clinical ultrasound contrast agent microbubbles remain intravascular and are between 1–8 µm in diameter, with a volume-weighted mean size of 2–3 µm. Despite their worldwide clinical utility as a diagnostic contrast agent, and their continued and ongoing success as a local therapeutic vector, the fundamental interplay between microbubbles – including bubble–bubble interaction and the effects of a neighboring viscoelastic vessel wall, remain poorly understood. In this work, we developed a finite element model to study the physics of the complex system of two different-sized bubbles (2 and 3 µm in diameter) confined within a viscoelastic vessel from a resonance response perspective (3–12 MHz). Here, we focus on the effect of micro-vessel wall viscosity on the resulting vibrational activity of the two-bubble system. The larger bubble (3 µm) was not influenced by its smaller companion bubble, and we observed a significant dampening effect across all transmit frequencies when confined within the vessel of increasing viscosity, an expected result. However, the smaller bubble (2 µm) was highly influenced by its larger neighboring bubble, including the induction of a strong low-frequency resonant response – resulting in transmit frequency windows in which its response in a lightly damped vessel far exceeded its vibration amplitude when unconfined. Further, micro-vessel wall dynamics closely mimic the frequency-dependence of the adjacent bubbles. Our findings imply that for a system of multi-bubbles within a viscoelastic vessel, the larger bubble physics dominates the system by inducing the smaller bubble and the vessel wall to follow its vibration – an effect that can be amplified within a lightly damped vessel. These findings have important implications for contrast-enhanced ultrasound imaging and therapeutic applications.
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微血管粘度对双微泡系统共振响应的影响。
临床超声造影剂微泡存在于血管内,直径在1-8µm之间,体积加权平均大小为2-3µm。尽管它们作为诊断造影剂在世界范围内的临床应用,并且它们作为局部治疗载体的持续和持续的成功,但微泡之间的基本相互作用-包括气泡-气泡相互作用和邻近粘弹性血管壁的影响-仍然知之甚少。在这项工作中,我们开发了一个有限元模型,从共振响应的角度(3-12 MHz)研究了粘弹性容器内两个不同大小的气泡(直径为2和3 μ m)的复杂系统的物理特性。在这里,我们重点研究了微血管壁粘度对双泡系统振动活性的影响。较大的气泡(3µm)不受较小的伴泡的影响,我们观察到,当被限制在粘度增加的容器中时,所有传输频率都有显著的阻尼效应,这是预期的结果。然而,较小的气泡(2µm)受到相邻较大气泡的高度影响,包括诱导强烈的低频共振响应,导致其在轻阻尼容器中的响应远远超过其无约束时的振动幅度的发射频率窗口。此外,微血管壁动力学密切模仿邻近气泡的频率依赖性。我们的研究结果表明,对于粘弹性血管内的多个气泡系统,较大的气泡物理通过诱导较小的气泡和血管壁跟随其振动来主导系统-这种效应可以在轻度阻尼的血管中被放大。这些发现对超声造影和治疗应用具有重要意义。
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来源期刊
Ultrasonics
Ultrasonics 医学-核医学
CiteScore
7.60
自引率
19.00%
发文量
186
审稿时长
3.9 months
期刊介绍: Ultrasonics is the only internationally established journal which covers the entire field of ultrasound research and technology and all its many applications. Ultrasonics contains a variety of sections to keep readers fully informed and up-to-date on the whole spectrum of research and development throughout the world. Ultrasonics publishes papers of exceptional quality and of relevance to both academia and industry. Manuscripts in which ultrasonics is a central issue and not simply an incidental tool or minor issue, are welcomed. As well as top quality original research papers and review articles by world renowned experts, Ultrasonics also regularly features short communications, a calendar of forthcoming events and special issues dedicated to topical subjects.
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