Topical Ivermectin-metronidazole gel therapy improves Meibomian gland Function in blepharitis caused by demodex spp.

IF 4.1 3区 医学 Q1 OPHTHALMOLOGY Contact Lens & Anterior Eye Pub Date : 2024-12-20 DOI:10.1016/j.clae.2024.102354
Marcel Y Ávila, Felipe Andrés Quesada, Edgar M Espana
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引用次数: 0

Abstract

Purpose: To evaluate the efficacy and safety of topical Ivermectin- Metronidazol in the management of demodex infestation and their effect in Meibomian gland dysfunction (MGD) METHODS: Fifty-four patients (108 eyes) with demodex diagnosis and Meibomian gland dysfunction received Ivermectin 0.3 %+Metronidazole 0.5 % gel in the night for 5 weeks. Parameters were evaluated before and 8 weeks after the last application of IVM-MTZ. This includes demodex counts, OSDI tests, non-invasive breakup time (NIBUT), average noninvasive breakup time (AvNIBUT), and infrared meibography with the determination of glandular dropout.

Results: A complete eradication of infestation was observed with the proposed treatment. A significant improvement in NIBUT, AvNIBUT, and OSDI score. The Meibomian gland improved with the treatment with a reduction of the glandular dropout from 50 ± 1.4 % to 39.05 ± 1.2 % (P < 0.0005) CONCLUSIONS: Management of demodex infestation in MGD improves tear film parameters, reduces ocular symptoms, and induces improvement in the anatomy of Meibomian glands. This is the first intervention that induces anatomical changes in Meibomian glands and must be considered as a modality for the treatment of MGD-demodex coexistence.

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来源期刊
CiteScore
7.60
自引率
18.80%
发文量
198
审稿时长
55 days
期刊介绍: Contact Lens & Anterior Eye is a research-based journal covering all aspects of contact lens theory and practice, including original articles on invention and innovations, as well as the regular features of: Case Reports; Literary Reviews; Editorials; Instrumentation and Techniques and Dates of Professional Meetings.
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Topical Ivermectin-metronidazole gel therapy improves Meibomian gland Function in blepharitis caused by demodex spp. Validation and repeatability assessment of the Chinese version of the Ocular Surface Disease Index (OSDI), 5-item dry eye (DEQ-5), and contact lens dry eye questionnaire-8 (CLDEQ-8) questionnaires. Artificial intelligence-assisted fitting method using corneal topography outcomes enhances success rate in orthokeratology lens fitting. Randomised controlled trial on effects of topical insulin compared to artificial tears and normal saline on tear inflammatory mediator levels and clinical parameters in diabetics with dry eye disease. Development and evaluation of ocular antibiotic-loaded soluble film inserts.
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