Factors Predictive of Success in Uncontrolled Donation After Circulatory Death in the Community of Madrid: An Analysis of Data From the Regional Registry of Donation and Transplantation (CORE Registry)

Abstract

Unfortunately, organ donation remains a challenge today. In Spain, uncontrolled Donation after Circulatory Death was introduced in cardiorespiratory arrests witnessed by out-of-hospital emergency services (OHES) to increase the number of donors. However, the selection of donor patients remains a challenge today.

Aim

to identify the variables that influence the number of organs for donation obtained from patients attended OHES. To use these variables to create a predictive model of transplant success.

Method

A retrospective, descriptive, analytical, cross-sectional study based on data from the Regional Registry of Donation and Transplantation (CORE registry) of the Community of Madrid from 2007 to 2017. Descriptive bivariate analysis was performed relating the organ donor (yes/no) variable with each of the study variables. Logistic regression models were performed with the variables and showed statistical significance using as principal variable the organ donor (yes/no) variable.

Results

A total of 550 patients were included. Mean age was 46.2 years (SD: 8.7), 86.4% (n = 473) male. Bivariate analysis found a relationship between the variable organ donor (yes/no) and age, weight, and body mass index (BMI) with P < .05. The predictive model showed the highest number of donors in the 45 to 55 years age group and BMI 25 to 30. Those aged over 60 with a BMI of 30 and above had a probability of organ donation of 40% or less.

Conclusions

In uncontrolled Donation after Coronary Death involving OHES there is a relationship between organ donation and age and BMI. Patients aged 45 to 55 with a BMI of 25 to 30 more frequently donate organs.