The impact of APOE4 on neurological symptoms after exposure to K. brevis neurotoxin

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES Environmental toxicology and pharmacology Pub Date : 2025-01-01 DOI:10.1016/j.etap.2024.104621

Gregory J. Aldrich , Aurore Nkiliza , Scott Ferguson , Daniel Niedospial , Dakota Helgager , Andrew P. Keegan , Daniel Paris , Barbara Kirkpatrick , Fiona Crawford , Michael Mullan , Laila Abdullah

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Abstract

Introduction

The harmful alga Karenia brevis (K. brevis) releases brevetoxins (PbTx) that cause respiratory and neurological symptoms. The apolipoprotein E (APOE) ε4 allele has been linked to poor neurological outcomes after exposure to environmental toxicants. This study explores the influence of the ε4 allele on the relationship between K. brevis in coastal waters and neurological symptoms reported by Southwest Florida residents.

Methods

A Surrogate Brevetoxin Exposure (SBE_air) index was developed to estimate aerosolized PbTx exposure. Data on past medical history and symptoms and blood for analyzing APOE genotypes were collected from 244 participants.

Results

Compared to non-carriers, ε4 carriers more frequently reported experiencing memory problems and fatigue during red tide blooms, independent of conditions like dementia and chronic fatigue syndrome.

Conclusion

This study suggests that the ε4 allele may exacerbate neurological symptoms from aerosolized PbTx, highlighting the need for strategies to better understand the impact of PbTx on the brain.

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APOE4对短梭菌神经毒素暴露后神经症状的影响

有害藻类短凯伦氏菌（k.b uvis）释放短毒素（PbTx），引起呼吸道和神经系统症状。载脂蛋白E (APOE) ε4等位基因与暴露于环境毒物后不良的神经预后有关。本研究探讨了ε4等位基因对佛罗里达西南部居民报告的沿海水域短链克雷伯氏菌与神经症状之间关系的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.