Xiongtao Ji, Na Wang, Jingkang Wang, Yunhai Huang, Ting Wang, Xin Huang, Hongxun Hao
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引用次数: 0
Abstract
Due to the unique drug delivery mode and specific therapy, nano‐formulations are of interest for biomedical applications and treating many diseases. However, traditional method of nano‐formulation construction via additional carriers or structural modifications of therapeutic drugs might be cumbersome or low loading‐efficient. Herein, the kinetics, accessible pathways, and final outcomes of supramolecular assembly processes of therapeutic drugs are investigated in detail. It was found that the supramolecular aggregates of cephradine (CEP) undergoes a morphological transformation from anisotropic nanofiber (EtOH) to isotropic spherical nanoparticle (H2O), similar to “plants took root, sprouted, blossomed and bore fruit.” Moreover, the assembly kinetics results reveal the assembly pathways of nucleation elongation in H2O and surface‐catalyzed secondary nucleation in EtOH. The method presented in this work has the potential to be used for efficiently designing specific nano‐formulations.
期刊介绍：
The AIChE Journal is the premier research monthly in chemical engineering and related fields. This peer-reviewed and broad-based journal reports on the most important and latest technological advances in core areas of chemical engineering as well as in other relevant engineering disciplines. To keep abreast with the progressive outlook of the profession, the Journal has been expanding the scope of its editorial contents to include such fast developing areas as biotechnology, electrochemical engineering, and environmental engineering.
The AIChE Journal is indeed the global communications vehicle for the world-renowned researchers to exchange top-notch research findings with one another. Subscribing to the AIChE Journal is like having immediate access to nine topical journals in the field.
Articles are categorized according to the following topical areas:
Biomolecular Engineering, Bioengineering, Biochemicals, Biofuels, and Food
Inorganic Materials: Synthesis and Processing
Particle Technology and Fluidization
Process Systems Engineering
Reaction Engineering, Kinetics and Catalysis
Separations: Materials, Devices and Processes
Soft Materials: Synthesis, Processing and Products
Thermodynamics and Molecular-Scale Phenomena
Transport Phenomena and Fluid Mechanics.
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