Iron Catalyzed Radical Alkylation of Cyclic Ketimines with olefins via Metal Hydride Atom Transfer

IF 4.4 2区化学 Q2 CHEMISTRY, APPLIED Advanced Synthesis & Catalysis Pub Date : 2024-12-23 DOI:10.1002/adsc.202401430

Xixi Hu, Ruizhi Sun, Yu Tian, Xinyue Xu, Yijia Zhu, Hui Liu, Dong Liu, Lizhi Zhang

引用次数: 0

Abstract

Here, we present an innovative approach to achieve Minisci-type alkylation of cyclic N-ketimines, enabling access to a diverse range of valuable alkylated sulfonyl ketimines via iron hydride hydrogen atom transfer. More than 35 examples are shown with a wide range of substrates. Additionally, this system is easy to operate and can be efficiently scaled up. Mechanistic investigations revealed that the alkyl radical process involved and the air acts as the sole oxidant in this system.

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金属氢化物原子转移催化环酮胺与烯烃自由基烷基化反应

在这里，我们提出了一种创新的方法来实现环n -酮胺的微型烷基化，使通过氢化铁氢原子转移获得各种有价值的烷基化磺酰基酮胺。超过35个例子显示了广泛的基板。此外，该系统易于操作，可以有效地扩大规模。机理研究表明，烷基自由基过程参与其中，空气是该体系中唯一的氧化剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.