{"title":"Copper and DMAP relay-catalyzed three-component coupling of terminal alkynes, anthranils and alcohols for the modular synthesis of 2-alkoxy quinolines","authors":"haixia Li, Yang Gao, xiongwei Zhong, Yanping Huo, Xianwei Li, Qian Chen","doi":"10.1002/adsc.202401293","DOIUrl":null,"url":null,"abstract":"A copper and DMAP relay-catalyzed strategy has been achieved for the modular synthesis of 2-alkoxy quinolines from a three-component coupling of terminal alkynes, anthranils, and alcohols. In this protocol, a novel quinoline pyridine salt is formed and serves as a key intermediate in the formation of 2-alkoxy quinolines. The reaction has a broad substrate scope of each reaction partners, affording diversified 2-alkoxy quinoline products in generally good yields.","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"23 1","pages":""},"PeriodicalIF":4.4000,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Synthesis & Catalysis","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1002/adsc.202401293","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
A copper and DMAP relay-catalyzed strategy has been achieved for the modular synthesis of 2-alkoxy quinolines from a three-component coupling of terminal alkynes, anthranils, and alcohols. In this protocol, a novel quinoline pyridine salt is formed and serves as a key intermediate in the formation of 2-alkoxy quinolines. The reaction has a broad substrate scope of each reaction partners, affording diversified 2-alkoxy quinoline products in generally good yields.
期刊介绍：
Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry.
The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
