{"title":"Regiodivergent Reactions of 2-Alkynl Aziridines with Grignard Reagents","authors":"Wen-Tao Ji, A-Nan Ping, Gaosheng Yang, Zhuo Chai","doi":"10.1002/adsc.202401311","DOIUrl":null,"url":null,"abstract":"Herein, we report regiodivergent nucleophilic attack of Grignard reagents to 2-alkynyl aziridines. Under the catalysis of a Cu(I)-diphosphine complex, benzylic Grignard reagents add to the carbon-carbon triple bond of the aziridines to deliver α-allenylamines in moderate to excellent yields; the direct addition of the Grignard reagents to the aziridines in the absence of catalyst provided\thomopropargylic amine derivatives. Both reactions could proceed in highly enantiospecific ways. Further synthetic manipulations of these products enable rapid access to diverse useful heterocyclic molecular scaffolds.","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"53 1","pages":""},"PeriodicalIF":4.4000,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Synthesis & Catalysis","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1002/adsc.202401311","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Herein, we report regiodivergent nucleophilic attack of Grignard reagents to 2-alkynyl aziridines. Under the catalysis of a Cu(I)-diphosphine complex, benzylic Grignard reagents add to the carbon-carbon triple bond of the aziridines to deliver α-allenylamines in moderate to excellent yields; the direct addition of the Grignard reagents to the aziridines in the absence of catalyst provided homopropargylic amine derivatives. Both reactions could proceed in highly enantiospecific ways. Further synthetic manipulations of these products enable rapid access to diverse useful heterocyclic molecular scaffolds.
期刊介绍:
Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry.
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