Causal Relationship and Potential Common Pathogenic Mechanisms Between Alopecia Areata and Related Cancer.

IF 1.9 4区医学 Q3 DERMATOLOGY Clinical, Cosmetic and Investigational Dermatology Pub Date : 2024-12-17 eCollection Date: 2024-01-01 DOI:10.2147/CCID.S496720

Zexin Zhu, Xiaoxue Wang

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Abstract

Objective: Alopecia areata (AA) is an autoimmune skin disease. Observational studies have reported an association between AA and cancer. However, the causal relationship between AA and cancer has not been reported. We employed a two-sample Mendelian randomization (MR) study to assess the causality between AA and 17 subtypes of cancers.

Methods: We employed a two-sample Mendelian randomization (MR) study to assess the causality between AA and 17 subtypes of cancers. AA and cancers' association genome-wide association study (GWAS) data were collected. The inverse variance weighted (IVW) method was utilized as the principal method in our Mendelian randomization (MR) study, with additional use of the MR-Egger, weighted median, simple mode, and weighted mode methods. After that, we explored the underlying biological mechanisms by Bioinformatic Analysis.

Results: According to our MR analysis, AA has a causal relationship with hepatic bile duct cancer (HBDC, (odds ratio [OR] = 0.944, 95% confidence interval [CI] = 0.896-0.994, P-value = 0.030) and colorectal cancer (CRC, OR = 0.981, 95% CI = 0.963-0.999, P-value = 0.046). AA could decrease the risk of HBDC and CRC. No causal link between AA and other subtypes of cancers was observed. No heterogeneity or pleiotropy was observed. Furthermore, disease-related genes were obtained, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis results showed that the set of genes associated with immunity-inflammatory signaling pathway.

Conclusion: This study provided new evidence of the relationship between AA with HBDC and CRC. AA may play a protective role in both HBDC and CRC progression. This could provide newer avenues for research in search of treatment for HBDC and CRC.

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斑秃与相关癌症的因果关系及潜在的共同致病机制。

目的：斑秃（AA）是一种自身免疫性皮肤病。观察性研究报道了AA和癌症之间的联系。然而，AA与癌症之间的因果关系尚未见报道。我们采用两样本孟德尔随机化（MR）研究来评估AA与17种癌症亚型之间的因果关系。方法：我们采用两样本孟德尔随机化（MR）研究来评估AA与17种癌症亚型之间的因果关系。收集AA和癌症全基因组关联研究（GWAS）数据。在我们的孟德尔随机化（MR）研究中，主要采用方差反加权（IVW）方法，另外还使用MR- egger、加权中位数、简单模式和加权模式方法。之后，我们通过生物信息学分析探讨了潜在的生物学机制。结果：根据我们的MR分析，AA与肝胆管癌（HBDC）（优势比[OR] = 0.944, 95%可信区间[CI] = 0.896-0.994， p值= 0.030）和结直肠癌（CRC）（OR = 0.981, 95% CI = 0.963-0.999， p值= 0.046）存在因果关系。AA可降低HBDC和CRC的发生风险。AA和其他亚型癌症之间没有因果关系。未观察到异质性或多效性。进一步获得疾病相关基因，基因本体（GO）和京都基因与基因组百科全书（KEGG）富集分析结果显示，这组基因与免疫-炎症信号通路相关。结论：本研究为AA与HBDC和CRC之间的关系提供了新的证据。AA可能在HBDC和CRC进展中发挥保护作用。这可能为寻找HBDC和CRC的治疗方法提供新的研究途径。

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来源期刊

Clinical, Cosmetic and Investigational Dermatology Medicine-Dermatology

CiteScore

2.80

自引率

4.30%

发文量

353

审稿时长

16 weeks

期刊介绍： Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal. Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest. The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care. All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.