Highly Sensitive and Selective Detection of Hg2+ ions and Antibacterial Activity Using a Schiff-base Derivative.

IF 2.6 4区 化学 Q2 BIOCHEMICAL RESEARCH METHODS Journal of Fluorescence Pub Date : 2024-12-22 DOI:10.1007/s10895-024-04070-4
Afnan M Alnajeebi, Rana Yahya, Alaa Shafie, Amal Adnan Ashour, Mohammed Fareed Felemban, Faris J Tayeb
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Abstract

A simple and highly effective Schiff-base fluorescent chemosensor (S1) was synthesized and characterized by 1HNMR and fluorescence spectroscopy. The synthesized chemosensor was applied for the selective and sensitive detection of Hg2+ ions. The chemosensor exhibited a strong 'turn-on' fluorescence response in a CH3OH/H2O (1:9, v/v) solution due to complex formation (S1-Hg2+) which block photo induce electron transfer (PET). The chemosensor showed significant sensitivity with very low detection limit of 2.0 ppb, making it suitable for trace-level Hg2+ detection. Furthermore, the S1-Hg2+ complex demonstrated excellent antibacterial activity against various Gram-positive and Gram-negative bacterial strains, broadening its utility beyond sensing. This dual-functional system offers significant potential in environmental and biomedical applications.

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希夫碱衍生物对Hg2+离子和抗菌活性的高灵敏度和选择性检测。
合成了一种简单高效的希夫碱荧光化学传感器(S1),并用1HNMR和荧光光谱对其进行了表征。将合成的化学传感器用于Hg2+离子的选择性和灵敏度检测。该化学传感器在CH3OH/H2O (1:9, v/v)溶液中表现出强烈的“开启”荧光响应,这是由于络合物的形成(S1-Hg2+)阻止了光诱导电子转移(PET)。该化学传感器具有显著的灵敏度,检测限极低,仅为2.0 ppb,适用于痕量Hg2+检测。此外,S1-Hg2+复合物对多种革兰氏阳性和革兰氏阴性菌株表现出优异的抗菌活性,拓宽了其应用范围。这种双功能系统在环境和生物医学应用方面具有巨大的潜力。
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来源期刊
Journal of Fluorescence
Journal of Fluorescence 化学-分析化学
CiteScore
4.60
自引率
7.40%
发文量
203
审稿时长
5.4 months
期刊介绍: Journal of Fluorescence is an international forum for the publication of peer-reviewed original articles that advance the practice of this established spectroscopic technique. Topics covered include advances in theory/and or data analysis, studies of the photophysics of aromatic molecules, solvent, and environmental effects, development of stationary or time-resolved measurements, advances in fluorescence microscopy, imaging, photobleaching/recovery measurements, and/or phosphorescence for studies of cell biology, chemical biology and the advanced uses of fluorescence in flow cytometry/analysis, immunology, high throughput screening/drug discovery, DNA sequencing/arrays, genomics and proteomics. Typical applications might include studies of macromolecular dynamics and conformation, intracellular chemistry, and gene expression. The journal also publishes papers that describe the synthesis and characterization of new fluorophores, particularly those displaying unique sensitivities and/or optical properties. In addition to original articles, the Journal also publishes reviews, rapid communications, short communications, letters to the editor, topical news articles, and technical and design notes.
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