A ubiquinone precursor analogue does not clearly increase the growth rate of Caenorhabditis inopinata.

microPublication biology Pub Date : 2024-12-05 eCollection Date: 2024-01-01 DOI:10.17912/micropub.biology.001235
Gavin C Woodruff, Kimberly A Moser
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Abstract

The evolution of developmental rates may drive morphological change. Caenorhabditis inopinata develops nearly twice as slowly as Caenorhabditis elegans . clk-1 encodes a hydroxylase required for synthesizing ubiquinone, and mutant clk-1 slow growth phenotypes can be rescued by supplying animals with a ubiquinone precursor analogue, 2,4-dihydroxybenzoate. RNA-seq data showing low clk-1 expression raised the possibility that C. inopinata grows slowly because of reduced ubiquinone biosynthesis. C. inopinata did not reveal a clear reduction in the age of maturation when reared on 2,4-dihydroxybenzoate. Further scrutiny of RNA-seq results revealed multiple ubiquinone metabolism genes have low expression in C. inopinata . Divergent clk-1 expression alone may not be a major driver of the evolution of slow development in this species.

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泛醌前体类似物不能明显提高隐杆线虫的生长速度。
发育速率的进化可能驱动形态的变化。棘杆线虫的发育速度几乎是秀丽隐杆线虫的两倍。Clk-1编码合成泛醌所需的羟化酶,突变体Clk-1生长缓慢的表型可以通过向动物提供泛醌前体类似物2,4-二羟基苯甲酸酯来拯救。RNA-seq数据显示低clk-1表达,这可能是由于泛醌生物合成减少导致的。当饲养在2,4-二羟基苯甲酸盐上时,不显示出成熟年龄的明显减少。对RNA-seq结果的进一步分析表明,多种泛素代谢基因在绿皮草中低表达。不同的clk-1表达本身可能不是该物种进化缓慢的主要驱动因素。
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