Osseointegration-Related Exosomes for Surface Functionalization of Titanium Implants.

IF 8.1 Q1 ENGINEERING, BIOMEDICAL Biomaterials research Pub Date : 2024-12-20 eCollection Date: 2024-01-01 DOI:10.34133/bmr.0124
Boqiong Li, Huanming Chen, Ruiqiang Hang
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Abstract

Despite that the clinical application of titanium-based implants has achieved great success, patients' own diseases and/or unhealthy lifestyle habits often lead to implant failure. Many studies have been carried out to modify titanium implants to promote osseointegration and implant success. Recent studies showed that exosomes, proactively secreted extracellular vesicles by mammalian cells, could selectively target and modulate the functions of recipient cells such as macrophages, nerve cells, endothelial cells, and bone marrow mesenchymal stem cells that are closely involved in implant osseointegration. Accordingly, using exosomes to functionalize titanium implants has been deemed as a novel and effective way to improve their osseointegration ability. Herein, recent advances pertaining to surface functionalization of titanium implants with exosomes are analyzed and discussed, with focus on the role of exosomes in regulating the functions of osseointegration-related cells, and their immobilization strategies as well as resultant impact on osseointegration ability.

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钛种植体表面功能化的骨整合相关外泌体。
尽管钛基种植体的临床应用取得了很大的成功,但患者自身的疾病和/或不健康的生活习惯往往导致种植体失败。许多研究已经进行了改良钛种植体,以促进骨整合和种植成功。最近的研究表明,外泌体是哺乳动物细胞主动分泌的细胞外囊泡,可以选择性地靶向和调节巨噬细胞、神经细胞、内皮细胞和骨髓间充质干细胞等受体细胞的功能,这些受体细胞与种植体骨整合密切相关。因此,利用外泌体对钛种植体进行功能化是提高其骨整合能力的一种新颖有效的方法。本文对近年来外泌体钛植入体表面功能化的研究进展进行了分析和讨论,重点讨论了外泌体在骨整合相关细胞功能调控中的作用、外泌体的固定策略以及对骨整合能力的影响。
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