Alterations of oscillatory activity and cognitive function after aneurysmal subarachnoid hemorrhage.

IF 12.5 2区医学 Q1 SURGERY International journal of surgery Pub Date : 2025-02-01 DOI:10.1097/JS9.0000000000002190

Peng Liu, Chuanliang Han, Tongyu Zhang, Yueqiao Xu, Kun Yang, Yuxia Li, Zhennan Ye, Changming Wang, Hongqi Zhang

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Abstract

Background: Aneurysmal subarachnoid hemorrhage (aSAH) can lead to cognitive impairment (CI), but underlying neural mechanisms remain to be elucidated.

Materials and methods: To predict long-term CI after aSAH, resting electroencephalography (EEG) was measured in 112 patients hospitalized with a diagnosis of aSAH ( n = 66) or unruptured intracranial aneurysms (controls) ( n = 46). A neuropsychological battery was administered 8-24 months after discharge.

Results: Power spectrum analysis in the parietal-occipital lobe showed significantly higher power theta vs. alpha oscillations in patients with CI after aSAH. The power of theta and alpha oscillations were significantly correlated with multiple cognitive scale scores on the neuropsychological battery. A neural model was established, which showed that connectivity between inhibitory and excitatory neurons in neural circuits contributed to changes in theta and alpha oscillations and CI in aSAH.

Conclusion: The data collection, analysis, and computational model established in this study can serve as a new paradigm for other clinical studies investigating CI.

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动脉瘤性蛛网膜下腔出血后振荡活动和认知功能的改变。

背景：动脉瘤性蛛网膜下腔出血（aSAH）可导致认知障碍，但其潜在的神经机制尚不清楚。材料和方法：为了预测aSAH后的长期认知功能障碍，对112例诊断为aSAH （n = 66）或未破裂颅内动脉瘤(UIA；对照组（n = 46）。出院后8至24个月进行神经心理学连续治疗。结果：顶叶-枕叶功率谱分析显示，aSAH后认知障碍患者的θ波功率明显高于α波功率。θ波和α波的强度与神经心理电池的多个认知量表得分显著相关。建立神经模型，发现神经回路中抑制性神经元和兴奋性神经元之间的连通性参与了aSAH患者theta和alpha振荡的改变和认知障碍。结论：本研究建立的数据收集、分析和计算模型可为其他认知障碍临床研究提供新的范式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International journal of surgery SURGERY-

CiteScore

17.70

自引率

3.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The International Journal of Surgery (IJS) has a broad scope, encompassing all surgical specialties. Its primary objective is to facilitate the exchange of crucial ideas and lines of thought between and across these specialties.By doing so, the journal aims to counter the growing trend of increasing sub-specialization, which can result in "tunnel-vision" and the isolation of significant surgical advancements within specific specialties.