International journal of surgery最新文献

Background: China continues to face a substantial burden of gastric cancer (GC), particularly with respect to metastasis-related mortality. However, population-based analyses of distant metastasis patterns in Chinese GC patients remain unavailable.

Methods: Global Burden of Disease (GBD) data on GC from the 1990 to 2021 period was obtained through the Global Health Data Exchange (GHDx) query tool and integrative data of 18 919 patients who underwent surgery were obtained from our hospital. Univariate and multivariate logistic regression identified independent risk factors for metastases, and survival analysis utilized univariate and multivariate Cox regression, Kaplan-Meier method, and log-rank test. Predictive nomograms were assessed using metrics such as the area under the curve (AUC), calibration curves, and decision curve analysis.

Results: According to the GBD database, GC demonstrates declining global trends in both incidence and mortality. Nevertheless, China continues to face a substantial GC burden, with progressive annual rises in distant metastasis prevalence and metastasis-related mortality. Clinical characteristics and temporal patterns vary significantly across metastatic types. Furthermore, metastatic profiles exhibit sex-, age-, and stage-specific variations. Univariate and multivariate regression analyses identified independent risk factors for overall GC metastasis and site-specific metastases. The resulting prediction models demonstrated excellent predictive accuracy for metastatic progression. The prognostic nomogram was developed to predict 1-, 5-, and 10-year overall survival (OS) in GC patients, with AUCs of 0.86 (0.84-0.88), 0.87 (0.85-0.89), and 0.80 (0.74-0.85) in the training set, respectively, which showed good discriminative ability.

Conclusions: In this study, metastatic spectrums across diverse patient subgroups and temporal patterns of metastasis in GC were investigated. Furthermore, we developed clinical predictive nomograms for various metastatic patterns and OS in GC, which enhance the understanding of metastatic behavior and provide a robust tool for personalized risk assessment and prognosis prediction.

Objectives: To evaluate the application value of three ChatGPT versions and Gemini in pathology report simplification tasks for prostate cancer.

Methods: This retrospective study assessed GPT-3.5, GPT-4.0, GPT-4o, and Gemini on pathology reports from 228 prostate cancer patients across two institutions. Data were split into internal (center 1, n = 171) and external (center 2, n = 57) cohorts. Using specific prompts, models generated simplified texts. The evaluation of outputs included three main dimensions: (1) human scoring by patients, clinicians, and pathologists; (2) readability scores; and (3) BERT-based semantic similarity scores. Statistical comparisons employed paired t-tests or Wilcoxon signed-rank tests. Statistical consistency between raters was assessed using squared weighted kappa, intraclass correlation coefficient(3,1), and percent agreement, with 95% confidence intervals calculated for all metrics.

Results: GPT-4o (Few-Shot) achieved the highest accuracy and comprehensiveness scores from pathologists, while Gemini demonstrated the best understandability. Patient and clinician understandability ratings were consistently high across models. Mean Reading Grade Level scores varied between internal and external datasets, with GPT-4o Few-Shot performing best overall. BERT-based semantic similarity scores demonstrated distinct trends across models, reflecting differences in text simplification strategies.

Conclusion: LLMs adopt distinct trade-off strategies between simplifying pathology reports and preserving their structure and logic, influenced by prompt design and textual style. Their application shows potential to enhance patient comprehension and clinical communication. Future work should focus on domain-specific fine-tuning to ensure safe and reliable clinical integration.

Background: Preoperative differentiation of precursor glandular lesions (PGL), minimally invasive (MIA), and invasive adenocarcinoma (IAC) in stage IA lung adenocarcinoma (LUAD) is critical for surgical planning but remains challenging due to overlapping CT features and interobserver variability. While existing artificial intelligence (AI) models focus predominantly on binary classification with limited multicenter validation, this study developed and validated a ternary classification framework using pretrained TabPFN and traditional machine learning (ML) algorithms based on AI-derived histogram features, benchmarking against intraoperative frozen section analysis.

Materials and methods: This multicenter retrospective study utilized preoperative CT scans from three institutions between September 2014 and October 2023. Data were divided into training, internal validation, and external test sets. Histogram features (n = 26) were automatically extracted using a commercial AI system (InferRead CT Lung). TabPFN and five ML algorithms were trained with selected clinical and histogram features. Performance was evaluated by accuracy, macro-AUC, sensitivity, specificity, and Cohen's Kappa. Statistical comparisons included DeLong tests for AUC and chi-square for categorical variables.

Results: The cohort comprised 584 stage IA LUAD patients (mean age 57.9 ± 11.0 years; 386 female), divided into training/validation sets (n = 412, center 1) and external test sets (n = 114, center 2; n = 58, center 3). TabPFN achieved macro-AUC of 0.781-0.911 and accuracy of 67.2-78.9% across external test sets, outperforming other ML algorithms. Of note, TabPFN achieved an overall better prediction accuracy compared to frozen section analysis on all test sets (internal: 92.3% vs 84.6%, P = 0.503; external 1: 87.5% vs 75%, P = 1.000; external 2: 67.2% vs 43.1%, P < 0.001). Subgroup analysis revealed superior performance for mGGN lesions (85%) on both external test sets.

Conclusions: TabPFN enables robust, generalizable ternary classification of LUAD subtypes, surpassing conventional ML and frozen section analysis. Its integration with automated histogram analysis offers a scalable solution for preoperative stratification of early-stage lung cancer.

Background: The obesity paradox - where overweight and mild obesity appear associated with improved survival in some cardiometabolic conditions - challenges clinical risk stratification. The inability of body mass index (BMI) to discriminate lean mass from fat, or visceral from subcutaneous adipose tissue, may underlie this paradox.

Methods: To evaluate whether direct measures of abdominal fat distribution and metabolic health status more strongly associate with cardiometabolic morbidity and mortality than BMI alone, and whether they clarify the observed obesity paradox. This cross-sectional analysis with prospective mortality follow-up included 15 925 adults from the 2011-2018 U.S. National Health and Nutrition Examination Survey (NHANES), a nationally representative cohort. Data analysis was performed from July 2025 to October 2025.

Results: Among 15 925 participants, higher VFI and VFI/SFI ratio were consistently associated with increased mortality, whereas higher SFI was protective. After full adjustment, the highest quartile of VFI was associated with significantly increased risk of all-cause [hazard ratio (HR), 1.67; 95% CI, 1.19-2.33] and cardiometabolic mortality (HR, 2.92; 95% CI, 1.44-5.93). The VFI/SFI ratio showed similarly strong associations (all-cause mortality HR, 1.75; 95% CI, 1.19-2.58; cardiometabolic mortality HR, 2.90; 95% CI, 1.42-5.90). In contrast, overweight and obesity class I showed a lower risk of all-cause mortality compared to normal weight (overweight HR, 0.74; 95% CI, 0.56-0.99). Fat distribution indices demonstrated a strong association with CMD incidence in older adult (≥45 years). Metabolically unhealthy status was also a significant mortality risk factor, particularly in females.

Conclusions: In this cross-sectional study of U.S. adults, visceral fat accumulation and an unfavorable fat distribution ratio were more strongly associated with mortality and CMD risk than BMI alone. The apparent survival advantage of elevated BMI was attenuated after accounting for fat distribution and metabolic health. These findings suggest that clinical assessment of obesity-related risk should incorporate measures of fat distribution and metabolic phenotype beyond BMI.

Background: Ureteral strictures constitute an important clinical problem due to the increasing number of cases. Endoscopy has an established but limited role in the treatment of ureteral strictures. Endoscopic treatment of other than single, short strictures results in a high recurrence rate and treatment failure. Promising tools are metallic stents available now on the urological market; however, there are no standardized indications for the treatment of ureteral strictures with the use of metallic stents. Study aim was to determine the features influencing the results of the self-expanding ureteral stents (SUS)-assisted endoscopic treatment. The secondary endpoint was to relate the etiology of the stricture to the effectiveness of the SUS-related endoscopic treatment.

Methods: In a retrospective, single-center study, we present our experience in implantation of 65 SUS in the treatment of ureteral strictures of different etiology. The assessment of the efficacy and safety of the treatment was performed by the author's quality of life questionnaire, number of serious complications (Clavien-Dindo > 3a), patency of the SUS during stenting and the possibility of full recovery of the ureteral stricture with endoscopic methods assisted by the SUS. Uni- and multivariate regression models have been applied to define treatment failure predictors.

Results: Effective treatment of ureteral strictures with the SUS can be achieved in patients with a short ureteral stricture which usually occur after point injury of the ureter, without significant thermal damage. In long ureteral strictures typical of inflammatory diseases, complications after radiotherapy, and extensive thermal damage, the treatment failure rate with the use of the SUS is high.

Conclusions: Univariate analysis identified strictures longer than 2 cm, a dilatation diameter below 14 F and impaired stent patency during stenting as significant predictors of treatment failure, of which the possibility of an appropriately wide dilation and the patency of the SUS resulted from the length of the stricture.

Background and aims: Recently, increasing studies have reported that Parkinson's disease (PD) may experience an increased incidence of venous thromboembolic events and complications for patients who undergo surgery. We aimed to explore the actual prevalence and risk factors of venous thromboembolism (VTE) for patients with PD as well as its influence on the operative outcomes.

Methods: We searched PubMed, Embase, and Cochrane library up to 1 May 2025 for observational studies exploring the risk factors of venous thromboembolic events or comparing the frequency of venous thromboembolic events and complications in PD and non-PD patients. The primary outcomes were the risk factors for and incidence of venous thromboembolic events in patients with PD. The secondary outcome was comparing the complications or adverse events between PD and non-PD patients. Two reviewers screened the titles and abstracts of searched records for qualified reports according to the including and excluding criteria and extracted the data independently.

Results: Finally, we totally identified 17 observational studies involving 760 380 patients for the present analysis. Our pooled results indicated that when compared to patients without PD, patients with PD had significantly higher incidence of venous thromboembolic events, including VTE (OR 1.35, 95% CI 1.11-1.65), deep vein thrombosis (DVT; OR 1.56, 95% CI 1.24-1.96) and pulmonary embolism (PE; OR 1.54, 95% CI 1.20-1.96), respectively. In addition, when comparing DVT (+) and DVT (-) in patients with PD, female patients with PD had a higher frequency of DVT (OR 2.45, 95% CI 1.47-4.06), patients with lower Barthel index [mean difference (MD) -11.5, 95% CI -20.85-2.15] and those with smaller abdominal circumference (MD -7.13 cm, 95% CI -9.99 to -4.26), respectively. When compared to PD patients without DVT, PD patients with DVT had significantly higher average real variability of systolic blood pressure (MD 3.2 mmHg, 95% CI 0.75-5.65), lower heart rate at admission (MD -3.32 bpm, 95% CI -6.58 to -0.06), higher D-dimer (MD 2.14 µg/mL, 95% CI 1.20-3.08), and longer duration of illness (MD 22.68 months, 95% CI 6.77-38.58), respectively. Our pooled analysis also indicated that PD increased complications and adverse events of patients receiving operation.

Conclusions: Patients with PD were more prone to venous thromboembolic events and had an increased incidence of intra- and post-operative complications. Though several risk factors of DVT were identified for Parkinson's patients, they need further demonstration with specific researches in the future. Greater vigilance should be exercised to make an informed decision regarding patient care and preferred healthcare setup for patients with PD.

Background: This study aimed to investigate the relationship between the timing of anticoagulation initiation and clinical outcomes in critically ill patients with sepsis-induced coagulopathy (SIC).

Methods: We conducted a retrospective cohort study using the MIMIC-IV database. Adult patients diagnosed with SIC (ISTH-SIC score ≥ 4) and receiving anticoagulation therapy during their ICU stay were included. Anticoagulation therapy was defined as administration of unfractionated heparin, low-molecular-weight heparin, vitamin K antagonists, or direct oral anticoagulants, as captured in medication records; additionally, a heparin-only analysis was performed given its predominant use in this population. Patients were stratified into early (≤ 48 hours post-ICU admission) or delayed (> 48 hours) anticoagulation groups. Baseline characteristics were balanced using propensity score matching (PSM). Primary outcomes included 28-day, 60-day, and 90-day mortality. Cox proportional hazard models were applied to assess survival differences across subgroups.

Results: Among 12 738 eligible patients, 10 689 received early anticoagulation and 2049 received delayed treatment. After PSM (n = 3986), delayed anticoagulation was associated with significantly lower 28-day mortality (15% vs 19%, P < 0.001), and similar reductions were observed at 60 and 90 days. Kaplan-Meier survival curves showed significantly better survival in the delayed group (P < 0.001). Subgroup analyses revealed that the survival benefit was more pronounced in patients aged >65 years, those without acute kidney injury (AKI), platelet count ≥ 100 × 109/L, Sequential Organ Failure Assessment score ≥ 6, and those treated with unfractionated heparin.

Conclusions: Among critically ill patients with SIC, delayed initiation of anticoagulation was independently associated with improved short- and medium-term survival. These findings support a phenotype-guided, time-stratified approach to anticoagulation in sepsis and highlight the need for prospective trials to validate optimal timing strategies.