Eunice Alves, Sandra Ventura, Sara Meirinho, André R T S Araujo, Amílcar Falcão, Márcio Rodrigues, Gilberto Alves
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引用次数: 0
Abstract
Epilepsy patients are at a higher risk of developing overweight and obesity. Given the thermogenic properties of Paullinia cupana (Guarana), this study aimed to evaluate a potential pharmacokinetic interaction between P. cupana extract and phenytoin in rats. Two pharmacokinetic studies were developed with P. cupana and phenytoin: a coadministration and a pre-treatment study. Plasma concentrations of phenytoin and its primary metabolite (5-(4-hydroxyphenyl)-5-phenylhydantoin) were determined by HPLC-DAD, and data were analysed by non-compartmental pharmacokinetic methods. Both studies demonstrated a significant delay in the time to reach peak plasma concentration of phenytoin and its primary metabolite. Furthermore, a lower extent of systemic exposure of its primary metabolite was found in the coadministration study. In addition, the pre-treatment study indicated weight loss in the experimental group. These results suggest that concurrent administration of P. cupana extract with phenytoin may compromise the drug's therapeutic efficacy.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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