{"title":"Association of visceral adiposity index and lipid accumulation product with frailty in U.S. adults: a cross-sectional study from NHANES.","authors":"Shaohua Yan, Ke Chai, Jiefu Yang, Hua Wang","doi":"10.1186/s12944-024-02410-8","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Frailty poses a considerable public health challenge because of its association with negative health consequences. Although obesity is recognized as a contributor to frailty, conventional measures fail to adequately account for the effects of visceral adiposity. The study aimed to investigate the associations between the visceral adiposity index (VAI) or lipid accumulation product (LAP) and frailty.</p><p><strong>Methods: </strong>This study used data from the National Health and Nutrition Examination Survey (NHANES), which included 5,279 participants aged ≥ 20 years. The VAI and LAP were calculated via recognized formulas, and frailty was evaluated via a deficit accumulation approach. We employed logistic regression and restricted cubic splines to assess the associations among LAP, VAI and frailty.</p><p><strong>Results: </strong>Out of 5,279 participants, 1,836 individuals were categorized as frail. According to the fully adjusted models, the highest VAI and LAP values were significantly associated with frailty, with adjusted ORs of 1.84 (95% CI: 1.40-2.42) and 2.47 (95% CI: 1.89-3.24), respectively, compared with the lowest values. A nonlinear relationship was identified between the LAP and frailty, with an inflection point of 1.589 (ln-transformed), whereas the VAI was linearly associated with frailty. Sensitivity analyses confirmed the robustness of these associations.</p><p><strong>Conclusion: </strong>The VAI and LAP are significantly related to frailty, highlighting the importance of visceral adiposity in frailty risk. These results increase the understanding of the metabolic underpinnings of frailty and may guide the development of targeted prevention strategies.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"23 1","pages":"417"},"PeriodicalIF":3.9000,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11665064/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lipids in Health and Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12944-024-02410-8","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Frailty poses a considerable public health challenge because of its association with negative health consequences. Although obesity is recognized as a contributor to frailty, conventional measures fail to adequately account for the effects of visceral adiposity. The study aimed to investigate the associations between the visceral adiposity index (VAI) or lipid accumulation product (LAP) and frailty.
Methods: This study used data from the National Health and Nutrition Examination Survey (NHANES), which included 5,279 participants aged ≥ 20 years. The VAI and LAP were calculated via recognized formulas, and frailty was evaluated via a deficit accumulation approach. We employed logistic regression and restricted cubic splines to assess the associations among LAP, VAI and frailty.
Results: Out of 5,279 participants, 1,836 individuals were categorized as frail. According to the fully adjusted models, the highest VAI and LAP values were significantly associated with frailty, with adjusted ORs of 1.84 (95% CI: 1.40-2.42) and 2.47 (95% CI: 1.89-3.24), respectively, compared with the lowest values. A nonlinear relationship was identified between the LAP and frailty, with an inflection point of 1.589 (ln-transformed), whereas the VAI was linearly associated with frailty. Sensitivity analyses confirmed the robustness of these associations.
Conclusion: The VAI and LAP are significantly related to frailty, highlighting the importance of visceral adiposity in frailty risk. These results increase the understanding of the metabolic underpinnings of frailty and may guide the development of targeted prevention strategies.
期刊介绍：
Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds.
Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.
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