The role of the triglyceride-glucose index as a biomarker of cardio-metabolic syndromes.

IF 3.9 2区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Lipids in Health and Disease Pub Date : 2024-12-23 DOI:10.1186/s12944-024-02412-6

Verena Gounden, Sridevi Devaraj, Ishwarlal Jialal

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Abstract

Background: The Triglyceride-glucose (TyG) index represents a simple, cost-effective, and valid proxy for insulin resistance. This surrogate marker has also been proposed as a predictor of metabolic and cardiovascular disease (CVD). In this descriptive review, we aimed to assess the utility of the TyG index as a predictive biomarker of cardiometabolic diseases.

Methods: A search was conducted in PubMed, and Web of Science to identify cross-sectional and more importantly prospective studies examining the use of the TyG index as a predictive biomarker. The following terms were utilized in addition to the TyG index: "insulin resistance", "metabolic syndrome", "diabetes"; "cardiovascular diseases".

Results: This descriptive review included thirty prospective studies in addition to cross-sectional studies. Following adjustment for confounding variables, an elevated TyG index was associated with a significantly increased risk for the development of Metabolic Syndrome (MetS), Type 2 Diabetes, hypertension, and CVD. Also in limited studies, the TyG index was associated with endothelial dysfunction, increased oxidative stress and a pro-inflammatory phenotype.

Conclusion: Overall, our findings support the use of the TyG index as a valid biomarker to assess the risk of developing MetS, T2DM, as well as atherosclerotic cardiovascular disease.

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甘油三酯-葡萄糖指数作为心脏代谢综合征的生物标志物的作用。

背景：甘油三酯-葡萄糖（TyG）指数是一种简单、经济、有效的胰岛素抵抗指标。该替代标志物也被认为是代谢和心血管疾病（CVD）的预测因子。在这篇描述性综述中，我们旨在评估TyG指数作为心脏代谢疾病的预测性生物标志物的效用。方法：在PubMed和Web of Science中进行搜索，以确定使用TyG指数作为预测性生物标志物的横断面和更重要的前瞻性研究。除TyG指数外，还使用了以下术语：“胰岛素抵抗”、“代谢综合征”、“糖尿病”；“心血管疾病”。结果：本描述性综述包括30项前瞻性研究和横断面研究。在调整混杂变量后，TyG指数升高与代谢综合征（MetS）、2型糖尿病、高血压和心血管疾病的发生风险显著增加相关。同样在有限的研究中，TyG指数与内皮功能障碍、氧化应激增加和促炎表型相关。结论：总的来说，我们的研究结果支持使用TyG指数作为有效的生物标志物来评估发生MetS， T2DM以及动脉粥样硬化性心血管疾病的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lipids in Health and Disease 生物-生化与分子生物学

CiteScore

7.70

自引率

2.20%

发文量

122

审稿时长

3-8 weeks

期刊介绍： Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.