Younghac Kim, Nayeon Choi, Eun-Hye Kim, Man Ki Chung, Young-Ik Son, Dongryul Oh, Yong Chan Ahn, Se-Hoon Lee, Hyun Ae Jung, Sehhoon Park, Jinyong Kim, Han-Sin Jeong, Myung-Ju Ahn
{"title":"Adjuvant sequential chemotherapy for salivary duct carcinomas: a retrospective comparative analysis.","authors":"Younghac Kim, Nayeon Choi, Eun-Hye Kim, Man Ki Chung, Young-Ik Son, Dongryul Oh, Yong Chan Ahn, Se-Hoon Lee, Hyun Ae Jung, Sehhoon Park, Jinyong Kim, Han-Sin Jeong, Myung-Ju Ahn","doi":"10.1159/000543281","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to report the efficacy and safety of adjuvant sequential chemotherapy after definitive treatment of salivary duct carcinoma (SDC) compared with the standard treatment alone (surgery with postoperative radiation therapy).</p><p><strong>Methods: </strong>This was a retrospective study of pathologically confirmed 135 SDC patients (study period 2009 to 2022). After curative surgery and adjuvant radiation therapy, 55 of 135 patients decided to receive additional chemotherapy (OP+RT+Chemo group), while 80 opted for surgery and radiation (OP+RT group). Treatment outcomes of overall survival (OS), disease-free survival (DFS), and distant-metastasis-free survival (DMFS) were compared using a propensity score matching (PSM) analysis.</p><p><strong>Results: </strong>Adjuvant chemotherapy consisted of three cycles of cisplatin-based regimen, which was well tolerated in most patients with minimal adverse events. Multivariable analyses indicated that the addition of chemotherapy did not improve OS (p = 0.05), DFS (p = 0.386), and DMFS (p = 0.735), although there was a trend toward favoring adjuvant chemotherapy in terms of OS. With PSM analysis, OS (OP+RT+Chemo to OP+RT, Hazard ratio [HR] = 0.40, 95% confidence interval [95%CI] = 0.12-1.29, p = 0.126), DFS (HR = 0.69, 95% CI = 0.30-1.56, p = 0.367) and DMFS (HR = 0.96, 95% CI = 0.46-1.99, p = 0.903) were not statistically different.</p><p><strong>Conclusions: </strong>Current cisplatin-based adjuvant chemotherapy did not significantly improve treatment outcomes of SDC patients over the surgery and adjuvant radiation. Further development or clinical studies are required to improve the outcomes of SDC, including chemotherapeutic, biomarkers, immune checkpoint inhibitors, or treatment strategies.</p>","PeriodicalId":19497,"journal":{"name":"Oncology","volume":" ","pages":"1-25"},"PeriodicalIF":2.5000,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oncology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000543281","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: This study aimed to report the efficacy and safety of adjuvant sequential chemotherapy after definitive treatment of salivary duct carcinoma (SDC) compared with the standard treatment alone (surgery with postoperative radiation therapy).
Methods: This was a retrospective study of pathologically confirmed 135 SDC patients (study period 2009 to 2022). After curative surgery and adjuvant radiation therapy, 55 of 135 patients decided to receive additional chemotherapy (OP+RT+Chemo group), while 80 opted for surgery and radiation (OP+RT group). Treatment outcomes of overall survival (OS), disease-free survival (DFS), and distant-metastasis-free survival (DMFS) were compared using a propensity score matching (PSM) analysis.
Results: Adjuvant chemotherapy consisted of three cycles of cisplatin-based regimen, which was well tolerated in most patients with minimal adverse events. Multivariable analyses indicated that the addition of chemotherapy did not improve OS (p = 0.05), DFS (p = 0.386), and DMFS (p = 0.735), although there was a trend toward favoring adjuvant chemotherapy in terms of OS. With PSM analysis, OS (OP+RT+Chemo to OP+RT, Hazard ratio [HR] = 0.40, 95% confidence interval [95%CI] = 0.12-1.29, p = 0.126), DFS (HR = 0.69, 95% CI = 0.30-1.56, p = 0.367) and DMFS (HR = 0.96, 95% CI = 0.46-1.99, p = 0.903) were not statistically different.
Conclusions: Current cisplatin-based adjuvant chemotherapy did not significantly improve treatment outcomes of SDC patients over the surgery and adjuvant radiation. Further development or clinical studies are required to improve the outcomes of SDC, including chemotherapeutic, biomarkers, immune checkpoint inhibitors, or treatment strategies.
期刊介绍：
Although laboratory and clinical cancer research need to be closely linked, observations at the basic level often remain removed from medical applications. This journal works to accelerate the translation of experimental results into the clinic, and back again into the laboratory for further investigation. The fundamental purpose of this effort is to advance clinically-relevant knowledge of cancer, and improve the outcome of prevention, diagnosis and treatment of malignant disease. The journal publishes significant clinical studies from cancer programs around the world, along with important translational laboratory findings, mini-reviews (invited and submitted) and in-depth discussions of evolving and controversial topics in the oncology arena. A unique feature of the journal is a new section which focuses on rapid peer-review and subsequent publication of short reports of phase 1 and phase 2 clinical cancer trials, with a goal of insuring that high-quality clinical cancer research quickly enters the public domain, regardless of the trial’s ultimate conclusions regarding efficacy or toxicity.
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