The plasticity of epithelial cells and its potential in the induced differentiation of gastric cancer.

IF 7 2区生物学 Q1 CELL BIOLOGY Cell Death Discovery Pub Date : 2024-12-24 DOI:10.1038/s41420-024-02275-x

Ziwei Yan, Yingnan Liu, Yuan Yuan

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Abstract

Cell plasticity refers to the deviation of cells from normal terminal differentiation states when faced with environmental and genetic toxic stresses, resulting in the phenomenon of transforming into other cell or tissue phenotypes. Unlocking phenotype plasticity has been defined as a hallmark of malignant tumors. The stomach is one of the organs in the body with the highest degree of self-renewal and exhibits significant cell plasticity. In this paper, based on the review of the characteristics of normal differentiation of gastric epithelial cells and their markers, the four main phenotypes of gastric epithelial cell remodeling and their relationship with gastric cancer (GC) are drawn. Furthermore, we summarize the regulatory factors and mechanisms that affect gastric epithelial cell plasticity and outline the current status of research and future prospection for the treatment targeting gastric epithelial cell plasticity. This study has important theoretical reference value for the in-depth exploration of epithelial cell plasticity and the tumor heterogeneity caused by it, as well as for the precise treatment of GC.

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上皮细胞的可塑性及其在胃癌诱导分化中的潜力。

细胞可塑性是指细胞在面临环境和遗传毒性胁迫时，偏离正常的终末分化状态，产生向其他细胞或组织表型转化的现象。解锁表型可塑性已被定义为恶性肿瘤的一个标志。胃是人体自我更新程度最高的器官之一，具有显著的细胞可塑性。本文在综述胃上皮细胞正常分化特征及其标志物的基础上，总结了胃上皮细胞重塑的四种主要表型及其与胃癌（GC）的关系。此外，我们总结了影响胃上皮细胞可塑性的调控因子和机制，并概述了针对胃上皮细胞可塑性治疗的研究现状和未来展望。本研究对深入探讨上皮细胞可塑性及其引起的肿瘤异质性，以及对胃癌的精准治疗具有重要的理论参考价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Death Discovery Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

8.30

自引率

1.40%

发文量

468

审稿时长

9 weeks

期刊介绍： Cell Death Discovery is a multidisciplinary, international, online-only, open access journal, dedicated to publishing research at the intersection of medicine with biochemistry, pharmacology, immunology, cell biology and cell death, provided it is scientifically sound. The unrestricted access to research findings in Cell Death Discovery will foster a dynamic and highly productive dialogue between basic scientists and clinicians, as well as researchers in industry with a focus on cancer, neurobiology and inflammation research. As an official journal of the Cell Death Differentiation Association (ADMC), Cell Death Discovery will build upon the success of Cell Death & Differentiation and Cell Death & Disease in publishing important peer-reviewed original research, timely reviews and editorial commentary. Cell Death Discovery is committed to increasing the reproducibility of research. To this end, in conjunction with its sister journals Cell Death & Differentiation and Cell Death & Disease, Cell Death Discovery provides a unique forum for scientists as well as clinicians and members of the pharmaceutical and biotechnical industry. It is committed to the rapid publication of high quality original papers that relate to these subjects, together with topical, usually solicited, reviews, editorial correspondence and occasional commentaries on controversial and scientifically informative issues.